High purity Fmoc-Gly-OH Supply price

Product Overview

Fmoc-Gly-OH (N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine) is an Fmoc-protected glycine derivative designed for solid-phase peptide synthesis, serving as a high-purity building block that introduces glycine residues while minimizing racemization and side reactions.

Key Advantages

Purity ≥99% (HPLC) — Reduces undefined impurities that can interfere with peptide coupling, improving final product yield and reproducibility.
Low racemization (<0.1%)— Preserves stereochemical integrity during activation and coupling, which is essential for producing therapeutic-grade peptides.
Solubility in DMF and DCM — Fully soluble up to 0.5 M in DMF at room temperature, enabling flexible reaction concentrations without heating or sonication.
Batch-to-batch consistency — Each batch is shipped with a certificate of analysis (COA) containing HPLC, melting point, and mass spectrometry data, ensuring reliable scale-up.
Flexible supply volume — Available in 25 g, 100 g, 500 g, and 1 kg packages, with volume-based pricing that lowers cost per gram for production-scale orders.

Specifications

The following parameters are based on the certificate of analysis issued by the manufacturer for each batch.

Parameter	Value	Remarks
Chemical Name	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycine	Commonly abbreviated as Fmoc-Gly-OH
CAS Number	29022-11-3	Unique registry number for substance identification
Molecular Formula	C17H15NO4	Consistent with Fmoc protection on glycine
Molecular Weight	297.31 g/mol	Calculated value
Purity	≥99%	Determined by HPLC on each batch
Appearance	White to off-white powder	Visual inspection under normal lighting
Melting Point	170–175 °C	Literature range; actual value reported on COA
Solubility	Soluble in DMF, DCM, THF	DCM solubility confirmed up to 0.2 M
Storage Conditions	−20 °C, dry, airtight	Avoid moisture and prolonged light exposure
Packaging Options	25 g, 100 g, 500 g, 1 kg	Custom pack sizes on request

Use Cases

Peptide synthesis researchers — Used as a routine building block for Fmoc-based solid-phase peptide synthesis in medicinal chemistry and method development.
Pharmaceutical R&D teams — Enables preparation of peptide drug candidates with high stereochemical purity during early-stage preclinical studies.
CRO/CMO manufacturers — Supports scaling from gram to kilogram quantities while maintaining consistent quality across batches.
Academic teaching laboratories — Provides a reliable and cost-effective reagent for graduate-level courses in peptide synthesis.
Biotech start-ups — Offers low minimum order quantities and competitive pricing for proof-of-concept experiments and small-scale process validation.

FAQ

What is the price of Fmoc-Gly-OH?
The price depends on quantity and purity. For research quantities (25–100 g) at ≥99% purity, typical unit prices range from $0.30 to $0.80 per gram. Contact the supplier for a current quotation.

Is Fmoc-Gly-OH stable at room temperature?
Short-term handling at room temperature is fine, but long-term storage should be at −20°C in a dry, airtight container. Under these conditions, the compound remains stable for at least 12 months from the date of analysis.

How do I dissolve Fmoc-Gly-OH in DMF?
Weigh the required amount and add to DMF, then stir at room temperature. For a 0.3 M solution, dissolve 89.2 mg of Fmoc-Gly-OH in 1 mL of DMF. Full dissolution occurs within a few minutes.

Can Fmoc-Gly-OH be used with HBTU activation?
Yes, it is compatible with standard HBTU/HOBt activation and other common coupling reagents like HATU and DIC. Racemization remains below 0.1% under standard coupling conditions.

What is the CAS number of Fmoc-Gly-OH?
The CAS number is 29022-11-3. Use this identification when ordering or referencing the compound in regulatory or chemical databases.

Does baishixing offer bulk quantities for manufacturing?
Yes, baishixing supplies Fmoc-Gly-OH at kilogram scale with volume discounts. Lead times and current pricing for bulk orders are available directly from the sales team.

Can I get a certificate of analysis (COA) for every batch?
Every shipment includes a COA with test results for HPLC purity, melting point, appearance, and mass spectrometry. Additional analytical data can be provided upon request.

What is the difference between Fmoc-Gly-OH and Boc-Gly-OH?
Fmoc-Gly-OH uses a base-labile Fmoc group removable under mild conditions, while Boc-Gly-OH requires acidic deprotection. Fmoc chemistry is preferred for solid-phase peptide synthesis due to its orthogonality and ease of monitoring.

Differentiation

Compared with other Fmoc-glycine suppliers, this product combines a high verified purity (≥99% HPLC), consistently low racemization (<0.1%), and complete documentation for each batch. The packaging range spans from 25 g research units to 1 kg production lots, which accommodates both early-stage discovery and commercial manufacturing. The pricing model offers transparent volume discounts, making it suitable for projects where cost per gram and quality reproducibility are equally important. For researchers and production teams that require a dependable supply chain with COA support, baishixing serves as a practical source for Fmoc-Gly-OH, and direct inquiry provides the most accurate supply price for specific quantities and purity grades.