Fmoc-Gly-OH 29022-11-3 Export Price

Fmoc-Gly-OH (CAS 29022-11-3) is a protected glycine derivative used primarily in solid-phase peptide synthesis (SPPS), designed for research and production environments that require consistent coupling efficiency and low racemization levels.

---

Core Selling Points

High HPLC purity ≥99.0% – Reduces unwanted by-products, minimizing purification time during peptide chain assembly.
Low single impurity ≤0.1% – Ensures cleaner coupling steps, which is critical when synthesizing peptides for biological assays or pharmaceutical studies.
Free amine content ≤0.1% – Prevents premature chain termination or side reactions, improving overall yield of target peptides.
Moisture content ≤0.5% (Karl Fischer) – Protects against hydrolysis during storage, especially important in humid environments or long-term inventory management.
Particle size consistency (80–120 mesh) – Supports smooth flow in automated synthesizer systems, reducing clogging risks in continuous production.

---

Detailed Specifications

Parameter	Value	Supplementary Notes
Product Name	Fmoc-Gly-OH (Fmoc-glycine)	Also known as 9-fluorenylmethyloxycarbonyl-glycine
CAS Number	29022-11-3	N/A
Molecular Formula	C₁₇H₁₅NO₄	N/A
Molecular Weight	297.31 g/mol	Calculated
Appearance	White crystalline powder	Matches reference standard under normal light
Assay (HPLC)	≥99.0%	Area normalization method
Single Impurity (HPLC)	≤0.1%	Excluding solvents and inorganic salts
Loss on Drying	≤0.5%	Dried at 105°C for 2 hours
Free Glycine Content	≤0.1%	Determined by TLC or amino acid analysis
Solubility	Soluble in DMF, DMSO, THF	Slightly soluble in DCM; insoluble in water
Storage Conditions	2–8°C, airtight, protected from light	Stable for 24 months under these conditions
Packaging Options	100 g, 500 g, 1 kg, 5 kg	Custom packaging available for bulk orders
Regulatory Compliance	USP/EP grade reference available	Certificate of Analysis issued with each batch

---

Application Scenarios

Peptide drug R&D scientists use Fmoc-Gly-OH as the first or middle residue in manual SPPS to create glycine-containing peptides, benefiting from its stable Fmoc protection and rapid coupling kinetics.
CRO/CMO production teams running automated peptide synthesizers rely on its consistent mesh size and low moisture content to maintain process reproducibility across multi-kilogram batches.
Biochemistry research groups preparing custom peptide libraries use Fmoc-Gly-OH to introduce glycine units with minimal racemization, which is essential for structure-activity relationship studies.
Pharmaceutical scale-up manufacturers use this product for GMP-like process development, leveraging its low impurity profile to simplify downstream purification and reduce solvent waste.
Diagnostics reagent companies manufacturing peptide-based antigens or capture probes use Fmoc-Gly-OH as a spacer or linker component, where high purity ensures minimal false positives in immunoassays.

---

Common Questions and Answers

What is the CAS number of Fmoc-Gly-OH?
The CAS number is 29022-11-3. This is the standard registry identifier used for procurement, shipping, and regulatory documentation.

How do I store Fmoc-Gly-OH for long-term stability?
Store at 2–8°C in an airtight container away from light. Under these conditions, the product remains stable for 24 months without significant loss of assay value.

Is Fmoc-Gly-OH soluble in dichloromethane (DCM)?
Fmoc-Gly-OH is slightly soluble in DCM. For SPPS, it is more commonly dissolved in DMF or DMSO at concentrations of 0.2–0.5 M.

What is the melting point of Fmoc-Gly-OH?
The melting point is 175–178°C. This value can be used as a quick identity check, but HPLC assay is the primary quality indicator.

Can I use Fmoc-Gly-OH for solid-phase peptide synthesis without additional recrystallization?
Yes, if the HPLC purity is ≥99.0% and free glycine is ≤0.1%, it can be used directly in standard Fmoc SPPS protocols without further purification.

What is the difference between Fmoc-Gly-OH and Boc-Gly-OH?
Fmoc-Gly-OH uses a base-labile 9-fluorenylmethyloxycarbonyl group, while Boc-Gly-OH uses an acid-labile tert-butyloxycarbonyl group. The Fmoc version is more common in modern SPPS due to milder deprotection conditions.

Does Baishixing provide a Certificate of Analysis with each batch?
Yes, every batch ships with a Certificate of Analysis that includes HPLC chromatogram, water content, and residual solvent data. Bulk orders also include batch-specific stability summaries.

---

Differentiation Summary

Fmoc-Gly-OH from Baishixing is positioned for users who prioritize batch-to-batch consistency and low impurity contribution to their peptide synthesis workflow. Compared to standard commercial grades, its narrow impurity profile and controlled particle distribution offer measurable advantages in automated synthesis and large-scale coupling steps. For laboratories or production lines that require a reliable glycine building block with complete documentation, this product provides a balanced combination of purity, physical handling, and supply-chain stability. Suitable for both research-grade applications and pre-GMP process development, it is not positioned as a low-cost raw material but as a quality-controlled intermediate that simplifies downstream purification and reduces repeat runs.