Fmoc-Gly-OH 29022-11-3 Manufacturer

time：2026-10-15

Fmoc-Gly-OH (CAS 29022-11-3) is a high-purity Fmoc-protected glycine derivative manufactured for solid-phase peptide synthesis, offering research laboratories and pharmaceutical producers a consistent building block for peptide drugs, diagnostic reagents, and academic studies.

Core Selling Points

Purity ≥ 99.0% (HPLC) – Ensures minimal by-products during peptide chain elongation, reducing the need for costly purification after each coupling step.
Free glycine ≤ 0.3% – Lower impurity levels improve coupling efficiency and reduce unwanted truncation in synthesizers.
Water content ≤ 0.5% (Karl Fischer) – Prevents hydrolysis of the Fmoc protecting group during long-term storage and automated synthesis runs.
Melting point 174–176 °C – Verifies crystalline identity and batch-to-batch consistency, aligned with pharmacopeial methods.
Freely soluble in DMF and DCM – Supports direct dissolution in standard peptide synthesis solvents without heating or sonication.
Custom packaging (1 g to 25 kg) – Provides flexible sourcing for R&D, pilot-scale, and full production batches, with dry inert-gas sealing.

Detailed Parameter Table

Parameter	Value	Supplementary Explanation
CAS number	29022-11-3	Registry identifier used in catalogs and regulatory filings
Molecular formula	C18H17NO4	Fmoc-protected glycine chemical structure
Molecular weight	311.33 g/mol	Theoretical monoisotopic mass
Appearance	White to off-white crystalline powder	Visual inspection per in-house QC
Purity (HPLC)	≥ 99.0%	Area percent at 210 nm wavelength; CoA provided
Melting point	174–176 °C	Differential scanning calorimetry (DSC) method
Free glycine	≤ 0.3%	Quantified by HPLC after derivatization
Fmoc-Gly-OH dimer	≤ 0.3%	Detected via RP-HPLC
Water content	≤ 0.5%	Karl Fischer titration
Residual solvents	≤ 0.5%	GC analysis, conforms to ICH Q3C
Heavy metals	≤ 10 ppm	ICP-MS method
Storage conditions	2–8 °C, sealed, dry, protected from light	Avoid moisture; nitrogen purge recommended

Applicable Scenarios

Peptide research laboratories – Chemists developing novel sequences use this high-purity Fmoc-Gly-OH to obtain clean coupling reactions and reliable HPLC traces for structure confirmation.
Pharmaceutical process development – Scale-up scientists validating peptide API routes depend on consistent batch-to-batch purity to reproduce reaction kinetics and yield.
CRO/CDMO workflow – Contract research and manufacturing organizations handling multiple synthesis projects value the low free-glycine content, which minimizes side reactions in long multi-step syntheses.
Custom peptide manufacturing – Suppliers producing research-grade or non-GMP peptides use this reagent as a cost-effective, stable source for repeated production campaigns.
Academic teaching laboratories – Undergraduate and graduate students performing solid-phase peptide synthesis require a stable, easy-to-handle protected amino acid; this product meets that demand with clear documentation.

Common Q&A

What is the purity of your Fmoc-Gly-OH?≥ 99.0% by HPLC area percent. Each shipment includes a certificate of analysis (CoA) showing actual retention time and purity result, tested at 210 nm.

How should I store Fmoc-Gly-OH?Store at 2–8 °C in the original sealed container. Keep away from moisture and light. If partial use occurs, purge the headspace with dry nitrogen before resealing.

Do you provide free samples before ordering?Yes, we offer a 10 g free sample with CoA and HPLC chromatogram. Shipping costs are invoiced separately; samples are dispatched within 48 hours of request.

What are typical impurities in your product?The main impurities are free glycine (≤ 0.3%), Fmoc-Gly-OH dimer (≤ 0.3%), and residual solvents (≤ 0.5%). Full MSDS and impurity profiles are available upon request.

Can I get bulk packaging for manufacturing?Yes. We supply 25 g, 100 g, 1 kg, and 25 kg options. Bulk quantities are packaged in aluminum-lined polyethylene bags with nitrogen fill. Custom drum sizes are also available.

Is your Fmoc-Gly-OH suitable for cGMP production?Our usual grade is non-GMP and manufactured under ISO 9001:2015. For cGMP requirements, dedicated documentation and change control can be arranged with a 20-day lead time.

How do you ensure batch-to-batch consistency?Every batch is tested by HPLC, DSC, and Karl Fischer analysis. Release data is recorded and retained for three years, and CoAs are archived for full traceability.

What are your shipping options for international orders?We ship worldwide via DHL, FedEx, and TNT. Small orders are shipped at ambient temperature; cold-chain transportation is available for sensitive destinations.

Differentiation Summary

Compared to other suppliers, baishixing provides Fmoc-Gly-OH with a narrow melting point range and stringent control of free glycine and dimer content, verified by complete analytical documentation in every batch. Our stock is managed under ISO 9001:2015, allowing next-day dispatch for standard quantities across most regions. This product is suited for researchers and production teams that need reproducible quality, practical lot documentation, and competitive pricing without relying on a premium brand label.

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