High quality Fmoc-Gly-OH 29022-11-3 Wholesale Price

Fmoc-Gly-OH (also known as Fmoc-glycine, CAS 29022-11-3) is a protected amino acid derivative used as a building block for solid-phase peptide synthesis (SPPS), offering researchers a reliable, high-purity reagent for producing peptides with predictable coupling efficiency and minimal racemization.

Core Selling Points

Purity ≥ 98% (HPLC) – Ensures consistent coupling efficiency in automated and manual peptide synthesizers, reducing purification efforts and batch-to-batch variation.
Appearance: White crystalline powder – Color stability indicates low impurity content, simplifying visual quality checks before use.
Water content ≤ 1.0% – Low moisture prolongs shelf life and prevents premature activation of the Fmoc group during storage or handling.
Melting point 82–87 °C – Reference range confirms correct crystalline form and is suitable for QC documentation in laboratory workflows.
Compatibility with standard Fmoc deprotection conditions (20% piperidine in DMF) – Works directly with common synthesis protocols without additional optimization.

Detailed Specification Table

Parameter Item	Value	Supplementary Notes
Product name	Fmoc-Gly-OH	Chemical name: N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine
CAS number	29022-11-3	Verified via SciFinder (accessed 2024)
Molecular formula	C17H15NO4	Monoisotopic mass: 297.10 Da
Molecular weight	297.31 g/mol	Calculated using standard atomic weights
Purity (HPLC)	≥ 98.0%	Area percent method, C18 reversed-phase column, UV detection at 254 nm
Appearance	White to off-white powder	Visual inspection per USP<851>guidelines
Melting point	82–87 °C	Determined by capillary method, not corrected
Loss on drying	≤ 1.0%	Dried at 60 °C under vacuum for 3 h
Solubility	Soluble in DMF, DMSO, acetonitrile; partially soluble in dichloromethane	Concentration ≥ 100 mg/mL in DMF at 25 °C
Storage conditions	2–8 °C, sealed, protected from light	Stable for 24 months under recommended conditions
Packaging options	25 g, 100 g, 500 g, 1 kg	Bulk packaging available on request

Source: Baishixing product specification sheet (lot-specific COA provided with each order).

Applicable Use Cases

Peptide researchers in academic or biotech labs – When performing routine SPPS of linear peptides, using Fmoc-Gly-OH with ≥98% purity reduces by-product formation, leading to higher final peptide yield.
Contract manufacturing organizations (CMOs) – For large-scale peptide production (e.g., GLP-1 analogues), this grade of Fmoc-Gly-OH allows reproducible processes with consistent quality across multiple batches.
Pharmaceutical R&D scientists – During lead optimization where glycine is a key flexibility-mediating residue, the low racemization potential of high-quality Fmoc-Gly-OH helps preserve stereochemistry in the final active pharmaceutical ingredient (API).
Peptide library automation users – When running high-throughput parallel synthesizers, stable solubility and quick dissolution in DMF (≥100 mg/mL) ensures accurate liquid handling and uniform coupling.
Educational intensives in organic synthesis – As a model compound for teaching solid-phase strategies, Fmoc-Gly-OH offers a safe, well-characterized starting material with straightforward analysis.

Frequently Asked Questions

1. What is the purity of Fmoc-Gly-OH from Baishixing?
High-performance liquid chromatography (HPLC) analysis indicates ≥98.0% area purity, with a certificate of analysis (CoA) provided for each lot.

2. How should I store Fmoc-Gly-OH after opening the container?
Keep it sealed at 2–8 °C and protect it from light. Under these conditions, the compound remains stable for at least 24 months.

3. Can Fmoc-Gly-OH be used in both manual and automated peptide synthesizers?
Yes. Its solubility in DMF (≥100 mg/mL) and consistent particle size allow accurate weighing and dissolution for both manual glass vessels and automated flow-based systems.

4. Does Fmoc-Gly-OH require any special handling before coupling?
No. It can be used directly as a 0.2–0.5 M solution in DMF. For difficult couplings, pre-activation with HBTU or HATU is recommended as per standard SPPS protocols.

5. What is the water content specification for this product?
Loss on drying is ≤1.0%. This low moisture level minimizes hydrolysis of the Fmoc group and maintains coupling efficiency over extended storage.

6. What is the CAS number for Fmoc-Gly-OH?
The CAS registry number is 29022-11-3. This identifier remains consistent across different commercial suppliers.

7. Is Fmoc-Gly-OH suitable for cGMP production?
Our product is routinely supplied to CMOs for non-GMP research scale and pre-clinical synthesis. For GMP-grade material, contact the manufacturer to arrange qualified assessment of the batch-specific documentation.

8. What packaging sizes are available for this product?
Standard sizes include 25 g, 100 g, 500 g, and 1 kg. Custom sizes can be supplied with adequate lead time.

Differentiation Summary

Compared to generic Fmoc-Gly-OH suppliers who often provide only basic purity data, Baishixing ensures documented consistency by delivering a product with tight specifications on water content, melting point, and appearance, all verified in a lot-specific CoA. While many competitors list "≥95%" purity without stating analytical conditions, our ≥98% HPLC purity is measured under standardized buffer systems, enabling direct comparison with results in your existing synthesis workflow. The recommended storage stability (24 months at 2–8 °C) and compatibility with common SPPS solvents make this product particularly suitable for researchers and production teams who require reproducible peptide quality without re-optimizing synthesis conditions. If you work on peptide synthesis, drug discovery, or commercial peptide manufacturing, Fmoc-Gly-OH from Baishixing provides a reliable, traceable amino acid building block backed by clear analytical evidence.