Fmoc-Gly-OH 29022-11-3 Order Price

Product Definition

Fmoc-Gly-OH (Fmoc-glycine, CAS 29022-11-3) is a protected amino acid derivative used as a foundational building block in solid-phase peptide synthesis, offering ≥98% purity at wholesale pricing for pharmaceutical R&D and contract manufacturing organizations.

Core Selling Points

Purity ≥98% (HPLC) – Reduces by-product accumulation during extended coupling cycles, improving final peptide yield and lowering purification costs.
Direct manufacturer pricing – Removes intermediary markups, providing cost stability for bulk orders from kilogram to metric ton quantities.
Lot-to-lot consistency with batch analysis – Every batch is tested for identity, purity, and residual solvents, ensuring reproducible synthesis conditions for scale-up.
Low moisture content (≤0.5%) – Minimizes hydrolysis side reactions during storage and handling, extending effective shelf life under recommended conditions.
Documented analytical package – Certificates of Analysis (COA), MSDS, and NMR/HPLC spectra are provided to support regulatory submissions and internal quality audits.

Detailed Parameter Table

Parameter	Value	Additional Notes
Chemical Name	Fmoc-Gly-OH	Also known as Fmoc-glycine
CAS Number	29022-11-3	PubChem CID: 34576
Molecular Formula	C17H15NO4	Contains fluorenylmethoxycarbonyl (Fmoc) group
Molecular Weight	297.31 g/mol	Calculated from standard atomic weights (IUPAC 2021)
Purity	≥98%	Determined by HPLC area normalization
Appearance	White crystalline powder	Visual inspection according to internal standard
Melting Point	174–178°C	Differential scanning calorimetry (DSC)
Loss on Drying	≤0.5%	Gravimetric analysis at 60 °C under vacuum
Solubility	Soluble in DMF, DMSO, THF	Clear solution at 10% w/v in DMF
Storage Conditions	2–8 °C, airtight, dry	Protect from light and moisture
Quality System	ISO 9001:2015	Manufacturing facility certified for quality management

Applicable Scenarios

Peptide drug R&D – Process chemists use Fmoc-Gly-OH as a starting monomer for synthesizing therapeutic peptides, ensuring high coupling efficiency in each chain-elongation cycle.
Contract manufacturing of known peptides – Production teams require large quantities of cost-effective glycine derivatives to meet batch schedules without compromising purity, especially when scaling from research grade to pilot lots.
Custom peptide synthesis services – CROs and academic core facilities benefit from consistent lot quality that reduces troubleshooting time during repetitive coupling steps.
General organic synthesis – Researchers incorporating glycine into non-peptide conjugates rely on the base-labile Fmoc group’s predictable removal under mild conditions (e.g., 20% piperidine in DMF).
Scale-up feasibility studies – Process engineering teams evaluate raw material quality, supply chain stability, and cost before transferring to pilot-scale reactors.

FAQ

What is Fmoc-Gly-OH used for?

Fmoc-Gly-OH is a Fmoc-protected glycine derivative used as a building block in solid-phase peptide synthesis (SPPS), where it introduces a glycine residue at any position of a growing peptide chain.

How does Fmoc-Gly-OH differ from Boc-Gly-OH?

Fmoc-Gly-OH carries a base-labile 9-fluorenylmethoxycarbonyl group, while Boc-Gly-OH carries an acid-labile tert-butyloxycarbonyl group. Fmoc chemistry avoids repeated acid exposure during deprotection, making it compatible with acid-sensitive linkers and side-chain protecting groups.

Can Fmoc-Gly-OH be used in large-scale manufacturing?

Yes, the product is supplied in bulk quantities (100 g to metric ton scale) and manufactured under an ISO 9001:2015 quality management system with full batch traceability and documentation.

What storage conditions are recommended to maintain stability?

Store Fmoc-Gly-OH at 2–8 °C in an airtight container, protected from light and moisture. Under these conditions, the product remains chemically stable for at least 36 months from the date of manufacture.

How is the purity value determined?

Purity is measured by high-performance liquid chromatography (HPLC) using area normalization, with a minimum threshold of 98%. Each batch’s COA includes the exact measured percentage and the chromatographic conditions used.

Is a Certificate of Analysis (COA) available for each batch?

Yes, a COA is issued for every batch, covering purity, appearance, melting point, loss on drying, and residual solvent analysis. A sample COA, MSDS, and NMR/HPLC spectra are available on request before ordering.

Does the manufacturer provide technical support for synthesis issues?

Yes, technical consultation is available for solubility troubleshooting, coupling protocol optimization, and storage questions related to this specific building block.

Differentiation Summary

Compared with third-party resellers who commonly distribute Fmoc-Gly-OH in small vials with variable pricing and inconsistent lot documentation, Baishixing’s direct-manufacturing model provides two structural advantages: predictable cost at scale and transparent quality documentation. The product’s ≥98% HPLC purity meets standard SPPS requirements, but the core differentiator is lot-to-lot consistency, which directly impacts the reproducibility of peptide yield and impurity profiles. For R&D teams, CROs, and production units that need a dependable glycine derivative at wholesale price, Baishixing offers verified analytical data, flexible bulk packaging, and direct technical communication—factors that are more difficult to obtain from smaller suppliers without their own manufacturing capacity. This product is best suited for organizations that prioritize raw-material stability over brand names or premium-priced catalog items.