High quality Fmoc-Gly-OH 29022-11-3 Factory Price

1. Introduction

Fmoc-Gly-OH (Fmoc-glycine, CAS 29022-11-3) is an Fmoc-protected glycine derivative used as a fundamental building block in solid-phase peptide synthesis (SPPS), providing researchers with a high-purity (≥99%) amino acid monomer for reproducible peptide assembly.

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2. Core Selling Points

High purity (≥99% by HPLC): Minimizes deletion sequences and by-product formation during peptide chain elongation, ensuring reliable experimental outcomes.
Low free amine content (≤0.1%): Prevents unwanted N-terminal capping reactions that can terminate peptide growth prematurely.
Low moisture content (≤0.5% by Karl Fischer): Ensures accurate molar weighing and consistent coupling stoichiometry in moisture-sensitive reactions.
White crystalline powder form: Easy to weigh, dissolve, and handle in standard laboratory workflows.
Batch-to-batch consistency with COA documentation: Every batch is tested for identity, purity, and solubility, with Certificate of Analysis (COA) supplied.
Stable under recommended storage conditions (2–8°C): Retains ≥99% purity for up to 24 months when stored airtight and protected from light.

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3. Detailed Specifications

Parameter	Value	Additional Notes
Product Name	Fmoc-Gly-OH (Fmoc-glycine)	CAS 29022-11-3
Molecular Formula	C₁₇H₁₅NO₄	Molecular weight: 297.31 g/mol
Appearance	White to off-white crystalline powder	Visual inspection
Purity (HPLC)	≥99.0%	Area normalization method
Melting Point	172–176°C	Differential scanning calorimetry
Loss on Drying	≤0.5%	4 hours at 60°C under vacuum
Free Amine Content	≤0.10%	Ninhydrin test
Chloride Content	≤0.05%	Ion chromatography
Heavy Metals	≤10 ppm	ICP-MS analysis
Solubility	Soluble in DMF, DMSO, THF; insoluble in water	50 mg/mL in DMF at 25°C
Storage Conditions	2–8°C, airtight, protected from light	Stable for 24 months from manufacture date
Packaging Options	25 g, 100 g, 500 g, 1 kg	Custom bulk packaging available

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4. Applicable Scenarios

Solid-phase peptide synthesis (SPPS): Used as the C-terminal building block or internal glycine residue in Fmoc/tBu strategy for assembling peptides of 5–50 amino acids in length.
Peptide drug development: Serves as a raw material for the synthesis of GLP-1 analogues, peptide hormones, and antimicrobial peptides in research and cGMP development workflows.
Combinatorial chemistry and library synthesis: Provides a reliable glycine building block with consistent coupling efficiency across automated parallel synthesizers.
Fragment-based peptide ligation: Acts as a protected glycine unit in the preparation of peptide fragments prior to native chemical ligation (NCL).
Academic teaching laboratories: Functions as a standard, well-characterized substrate for training researchers in SPPS techniques and peptide characterization methods.

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5. Common Questions

What is the purity grade of Fmoc-Gly-OH?The product is supplied at ≥99% purity determined by HPLC area normalization, with a Certificate of Analysis provided for every batch.

What is Fmoc-Gly-OH used for?It is used as an amino acid building block in Fmoc-solid-phase peptide synthesis, particularly for incorporating glycine residues into synthetic peptides.

How should Fmoc-Gly-OH be stored?Store at 2–8°C in an airtight container protected from light. Under these conditions, the product remains stable for 24 months from the date of manufacture.

What is the solubility of Fmoc-Gly-OH?It is soluble in organic solvents such as DMF, DMSO, and THF. A typical working concentration is 50 mg/mL in DMF. It is not soluble in water.

**Does Fmoc-Gly-OH come with a Certificate of Analysis (COA)? Yes, each batch is quality-tested and a COA documenting purity, loss on drying, free amine content, and other specifications is supplied with the shipment.

Can I request bulk packaging for large-scale synthesis?Yes, bulk packaging from 1 kg to multi-kilogram quantities is available. Contact the supplier to discuss custom packaging and volume pricing options.

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6. Differentiation Summary

Fmoc-Gly-OH from [baishixing] is distinguished by its strict quality control metrics—purity ≥99%, free amine ≤0.1%, and moisture ≤0.5%—which directly translate into more reliable coupling efficiency and fewer failed peptide synthesis runs compared to products with lower specifications. While some suppliers offer technical-grade glycine derivatives at lower price points, the enhanced purity profile of this product is best suited for researchers and manufacturers who require reproducible results in diagnostic peptide production. The comprehensive batch documentation, including COA and HPLC chromatograms for each shipment, provides the traceability that regulatory and academic laboratories require. For laboratories prioritizing synthetic yield, minimal purification burden, and data integrity, this product is the appropriate choice.