Baishixing High-Quality Fmoc-Gly-OH

Product Definition

Baishixing High-Quality Fmoc-Gly-OH is a Fmoc-protected glycine derivative designed for researchers in peptide chemistry who need high purity and lot-to-lot consistency to avoid coupling failures and purification challenges.

Core Selling Points

Purity ≥99% (HPLC): Reduces by-product formation and simplifies final peptide purification.
Free amine content<0.1%:Prevents chain termination and ensures efficient stepwise elongation in solid-phase synthesis.
Water content ≤0.5% (Karl Fischer): Minimizes hydrolysis of the active ester and improves coupling reproducibility.
Batch-specific COA with full analytical data: Provides traceability for regulatory submissions and research documentation.
Packaged under argon in moisture-resistant containers: Maintains chemical integrity during long-term storage.

Detailed Specifications

Parameter	Value	Notes
Chemical name	N-Fmoc-glycine	Also known as Fmoc-Gly-OH
CAS number	29022-11-3	Confirmed by CAS registry
Molecular formula	C17H15NO4
Molecular weight	297.31 g/mol	Atomic weights per IUPAC
Appearance	White to off-white powder	Visual inspection
Purity (HPLC)	≥99%	Area normalization
Free amine (Ninhydrin)	<0.1%	Against glycine standard
Water content (Karl Fischer)	≤0.5%
Melting range	174–178 °C	Decomposition may occur
Solubility	Soluble in DMF, DMSO, DCM	100 mg/mL in DMF at 25 °C (typical)
Storage conditions	2–8 °C, desiccated	Protect from light
Shelf life	36 months from manufacturing date	When unopened under recommended storage
Packaging sizes	25 g, 100 g, 500 g	Custom bulk packaging available

Specifications based on the product's certificate of analysis and technical data sheet.

Application Scenarios

Drug discovery research: Yields reliable Fmoc-glycine coupling in the synthesis of peptide-based lead compounds, minimizing sequence truncation.
Automated peptide synthesis: Free-flowing powder is directly compatible with standard peptide synthesizers, reducing pump clogging issues.
Academic teaching laboratories: Offers consistent results that help students learn solid-phase peptide chemistry without unexpected side reactions.
Process development and scale-up: Provides stable batch quality that supports the transfer of synthetic methods from research to commercial scale.

Frequently Asked Questions

What is the CAS number of Fmoc-Gly-OH?
The CAS number is 29022-11-3.

What purity grade is available?
The product is offered with ≥99% purity measured by HPLC, ensuring low impurity levels.

How should I store this product?
Store in a tightly sealed container at 2–8 °C, protected from moisture and light.

Can I use this Fmoc-Gly-OH for solid-phase peptide synthesis?
Yes, it is specifically developed for SPPS and works with both Fmoc/tBu and Boc strategies.

Does the product contain racemization by-products?
The synthesis route is designed to minimize racemization; the free amine test confirms<0.1% racemized glycine.

What solvents are suitable for dissolving this product?
It dissolves readily in DMF, DMSO, and DCM; DMF is recommended for standard coupling reactions.

Is a certificate of analysis provided?
Yes, a batch-specific COA including HPLC, KF, and MS data is available for each order.

What custom packaging options exist?
We offer 25 g, 100 g, and 500 g units, and can quote for kilogram quantities or custom container sizes.

Differentiation Summary

Compared to generic Fmoc-Gly-OH suppliers, Baishixing’s product emphasizes tightly controlled specifications such as low free amine and strict moisture limits, which directly translate to fewer coupling failures in long peptides. Its full analytical documentation and argon atmosphere packaging make it a dependable choice for researchers transitioning from method development to GMP-oriented production. The combination of high purity and consistent batch performance positions this Fmoc-Gly-OH as a cost-effective alternative for laboratories that value reproducibility.