Price of Fmoc-Gly-OH 29022-11-3

Fmoc-Gly-OH (Fmoc-glycine, CAS 29022-11-3) is a high-purity amino acid building block used by peptide chemists and pharmaceutical manufacturers for solid-phase peptide synthesis, addressing the need for reliable coupling reagents that minimize racemization and ensure reproducible product yields.

Core Selling Points

Purity ≥98% (HPLC): Reduces side reactions and guarantees consistent coupling efficiency in automated or manual peptide synthesizers, which directly impacts final product yield.
CAS 29022-11-3 (molecular formula C₁₇H₁₅NO₄, MW 297.31): Provides a verified chemical identity, eliminating uncertainty in raw material verification for GMP and R&D workflows.
Stable Fmoc protecting group: Standard piperidine-based deprotection (20% v/v in DMF) works effectively, shortening cycle times without special handling requirements.
Low racemization during coupling: Preserves optical purity in the growing peptide chain, especially important for synthesizing therapeutic peptides or protein fragments.
Flexible packaging sizes (25 g, 100 g, 500 g, bulk): Allows research labs to scale from pilot experiments to production batches without changing suppliers or re-qualifying raw materials.

Technical Specifications

Parameter	Value	Supplementary Notes
Chemical Name	N-fluorenylmethoxycarbonyl-glycine (Fmoc-Gly-OH)	Standard Fmoc-protected amino acid
CAS Number	29022-11-3	Unique identifier for registry purposes
Molecular Formula	C₁₇H₁₅NO₄	Confirmed by elemental analysis
Molecular Weight	297.31 g/mol	Calculated mean value
Purity	≥98% (HPLC)	Determined by area normalization method
Appearance	White to off-white powder	Visual inspection
Loss on Drying	≤0.5%	Measured at 105°C for 3 hours
Solubility	Soluble in DMF, DCM, THF	Slightly soluble in methanol; insoluble in water
Storage Condition	2–8°C, protected from light	Store in tightly sealed container
Shelf Life	24 months from manufacture date	When stored as recommended
Packaging	25 g, 100 g, 500 g, custom bulk	Aluminum foil bag or HDPE bottle with desiccant

Applicable Scenarios

Peptide drug R&D laboratories: Researchers use Fmoc-Gly-OH as a building block in lead optimization, where high purity enables accurate dose-response data without interference from by-products.
Contract development and manufacturing organizations (CDMOs): When producing peptide APIs under cGMP conditions, this reagent provides batch-to-batch consistency and documented quality to meet regulatory submission requirements.
Academic teaching labs: Students training in solid-phase peptide synthesis benefit from a stable, easy-to-handle amino acid that produces predictable results in standard microwave or room-temperature protocols.
Pharmaceutical quality control departments: Analysts use Fmoc-Gly-OH to prepare reference standards or spiking solutions, relying on its defined molecular weight and chromatographic purity.
Peptide library screening programs: Research teams performing parallel synthesis generate cleaner screening hits when coupling reagents exhibit low racemization and high solubility in common solvents.

Common Questions and Answers

Why does the price of Fmoc-Gly-OH vary across suppliers?
Price differences mainly reflect purity level, manufacturing scale, packaging size, and quality documentation. A product with ≥98% HPLC purity and complete COA may cost 10–20% more than an uncharacterized batch, but the higher price reduces failure risk in sensitive syntheses.

What is the typical price range for Fmoc-Gly-OH in research quantities?
For 25 g to 100 g packs, the market price typically ranges from $50 to $200 depending on purity and supplier location. Bulk quantities above 1 kg are usually quoted individually because logistics and customization affect the unit price.

Can I store Fmoc-Gly-OH at room temperature?
No. The Fmoc group can gradually hydrolyze in humid conditions. Storage at 2–8°C in a desiccator and away from light maintains purity above 98% over the stated shelf life.

Is Fmoc-Gly-OH soluble in water?
No. It is practically insoluble in water. Use dimethylformamide (DMF), dimethylacetamide, or dichloromethane to dissolve it for coupling reactions. If you need an aqueous-compatible alternative, consider using a hydrochloride salt of glycine methyl ester.

How do I confirm the batch quality before bulk purchase?
Request a Certificate of Analysis (COA) covering HPLC purity, loss on drying, and specific rotation. Consider a small pilot test in your standard reaction before ordering large quantities.

Does baishixing provide bulk pricing for industrial scale?
Yes, baishixing offers tiered pricing for 500 g and multi-kilogram orders, with custom packaging and batch documentation. Contact their sales team with your annual volume to receive a valid quotation.

What if the HPLC purity is slightly below 98%? Does it affect peptide synthesis?
A purity of 95–97% may introduce tiny amounts of glycine lacking Fmoc protection or other impurities. In high-throughput synthesis, even 2% extra impurity can complicate purification. For clinical-grade peptides, purity above 99% is often specified.

Differentiation Summary

Compared with generic Fmoc-Gly-OH products that offer limited traceability, this reagent from baishixing delivers a defined purity threshold, complete analytical documentation, and packaging options that match both R&D and production needs. Its main advantage lies in the combination of verified quality and flexible procurement terms, making it suitable for laboratories that prioritize reproducibility and cost control. While some suppliers offer lower-priced batches without full certificates, researchers who require reliable coupling performance and regulatory support will benefit more from a product that provides consistent specifications and a transparent supply chain. For peptide synthesis teams that value batch-to-batch reliability over minimal upfront savings, this Fmoc-Gly-OH is a practical choice.