High purity Fmoc-Gly-OH Marke quotation

Fmoc-Gly-OH (N-(9-fluorenylmethoxycarbonyl)-glycine, CAS 29022-11-3) is an Fmoc-protected glycine building block designed for solid-phase peptide synthesis, serving pharmaceutical R&D teams, CDMO production facilities, and academic laboratories that require a high-purity glycine monomer with low racemization, stable batch consistency, and moisture resistance.

Core Advantages

HPLC purity ≥98.0% – Reduces crude peptide impurity load from the first coupling step, shortening downstream purification time and lowering solvent consumption per manufacturing cycle.
Melting point 173–178 °C (DSC) – Gives QC teams a fast identity confirmation in under five minutes without relying on LC-MS or NMR.
Loss on drying ≤0.5% – Prevents unwanted Fmoc deprotection during extended or automated chain assembly, especially in humid production environments.
Heavy metals ≤10 ppm (ICP-MS) – Meets tolerance limits for chemical intermediates used in phase I clinical manufacturing under ICH Q3D guidance.
24-month stability at 2–8 °C – Enables procurement teams to plan multi-step campaigns without periodic re-testing expenses.

Technical Specifications

Parameter	Value	Supplementary Notes
Product Name	Fmoc-Gly-OH	N-(9-Fluorenylmethoxycarbonyl)-glycine
CAS Number	29022-11-3	Standard registry identifier
Molecular Formula	C₁₇H₁₅NO₄	Confirmed by HRMS
Molecular Weight	297.31 g/mol	Monoisotopic mass: 297.1000
Purity (HPLC)	≥98.0%	Area normalization, UV 254 nm
Appearance	White crystalline powder	Visual inspection
Melting Point	173–178 °C	Differential scanning calorimetry
Loss on Drying	≤0.5%	105 °C, 3 hours
Heavy Metals	≤10 ppm	ICP-MS method
Solubility	Soluble in DMF, DMSO, THF; insoluble in H₂O	DMF is the typical process solvent
Storage Condition	2–8 °C, sealed, light protected	Protect from moisture
Shelf Life	24 months	Under specified storage conditions
Packaging	10 g, 25 g, 100 g, 1 kg	Custom bulk packaging available

Application Scenarios

CDMO peptide manufacturing – Process engineers building GLP-1 analogues (semaglutide, liraglutide) or teriparatide intermediates use this monomer at the N-terminal position, where ≥98% initial purity directly influences final API yield.
Academic peptide library synthesis – Researchers assembling 30–100 mer peptides on automated synthesizers depend on consistent coupling performance to minimize deletion sequences in glycine-rich regions.
Antibody-drug conjugate development – Medicinal chemists coupling glycine spacers into ADC payload linkers benefit from the ≤10 ppm heavy metal ceiling, which prevents interference with palladium-based chemistry.
Analytical reference standard – QC laboratories verifying HPLC methods for peptide purity use this material as a reference standard, backed by documented DSC curves and mass spectral data.
Immunoassay reagent production – IVD manufacturers synthesizing peptide antigens for ELISA kits value the 24-month shelf life for batch scheduling flexibility.

Market Reference Quotation (Indicative, Q3 2025)

Prices compiled from public catalog listings (Sigma-Aldrich, Chem-Impex, VWR) and Chinese export broker quotes (Shanghai/Ningbo ports) observed in July 2025. These are reference figures only; final pricing depends on quantity, Incoterms, and contract duration.

Purchase Quantity	Typical Channel	Indicative Unit Price (USD)	Notes
10–25 g	Research chemical catalogs	$1.00–$2.50 per gram	Includes CoA, SDS, small-pack surcharge
100–500 g	Specialty chemical distributors	$0.70–$1.20 per gram	FOB or EXW mainland China
1–10 kg	Direct manufacturer supply	$0.35–$0.80 per gram	Annual contract or bulk commitment

Frequently Asked Questions

1. What is Fmoc-Gly-OH used for?It is a protected glycine monomer for solid-phase peptide synthesis, used to insert glycine residues into peptide chains without requiring side-chain protection.

2. What is the CAS number of Fmoc-Gly-OH?CAS 29022-11-3. This registry number is required for purchasing, SDS compliance, and customs clearance.

3. What is the molecular weight of Fmoc-Gly-OH?297.31 g/mol for C₁₇H₁₅NO₄. Use this value for all molar and equivalent-weight calculations in resin loading.

4. How should Fmoc-Gly-OH be stored?Keep the container sealed at 2–8 °C, protected from light and moisture. Under these conditions, purity remains ≥98% for 24 months.

5. Is Fmoc-Gly-OH soluble in water?No. It dissolves readily in DMF, DMSO, and THF, but is insoluble in water. DMF is the most common solvent for SPPS couplings.

6. What purity level does baishixing guarantee?A minimum of 98.0% by HPLC area normalization at UV 254 nm, verified on every batch before release.

7. Does baishixing provide a Certificate of Analysis?Yes. Each batch ships with a CoA covering purity, melting point, loss on drying, heavy metals, and visual appearance.

8. Can Fmoc-Gly-OH be used in microwave-assisted SPPS?Yes. The Fmoc group remains stable under standard microwave cycles (up to 75 °C with HATU/DIPEA activation), and the ≤0.5% residual moisture prevents premature deprotection.

Differentiation Summary

Fmoc-Gly-OH from baishixing is positioned for teams that prioritize documented reproducibility over the lowest available unit price. Many suppliers certify only HPLC purity at release; this product goes further by restricting the melting range to 173–178 °C, capping residual water at 0.5%, and holding heavy metals to 10 ppm—parameters that directly reduce unexpected failure modes in long peptide sequences and scaled GMP campaigns. For procurement managers comparing regional resellers, the combination of full CoA transparency, cold-chain stability, and enforced quality specifications makes this a more predictable choice for regulated development workflows.