Fmoc-Gly-OH Supplier From China

This document provides a factual overview of Fmoc-Gly-OH (CAS 29022-11-3), a high-purity protected amino acid supplied by Baishixing, intended for research and industrial peptide synthesis, addressing the need for a reliable and documented raw material source.

Core Selling Points

Purity ≥99.0% (HPLC) – Each production lot meets the stated purity threshold, with free glycine content below 0.3%. This reduces the risk of truncated peptide impurities during Fmoc solid-phase stepwise coupling.
Residual solvents controlled per ICH Q3C – Solvent levels are measured and reported on the certificate of analysis (COA), which helps peptide manufacturers meet regulatory expectations for later-stage clinical materials.
Water content ≤1.0% (Karl Fischer) – Low moisture limits premature Fmoc cleavage and improves the accuracy of weighing and molar dosing in automated synthesizer loading.
Batch-size flexibility from 25 g to 25 kg – Packaging options support both laboratory development and commercial production without changing the manufacturing route or analytical standards.

Detailed Parameter Table

Parameter	Value	Supplementary Description
Product name	Fmoc-Gly-OH / Fmoc-glycine	Systematic name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycine
CAS number	29022-11-3	Unique registry number for chemical databases and customs forms
Molecular formula	C₁₇H₁₅NO₄	Consistent with the expected structure
Molecular weight	297.31 g/mol	Used for molar equivalent calculations in peptide synthesis
Appearance	White to off-white crystalline powder	Visual inspection per lot
Purity (HPLC)	≥99.0%	Area normalization at 210 nm or 254 nm, method stated on COA
Free glycine	≤0.3% (HPLC)	Monitored to control this main process-related impurity
Water content	≤1.0% (Karl Fischer)	Lower water is required for long-term storage stability
Residual solvents	Acetonitrile, methanol, ethyl acetate individually ≤0.5%; meet ICH Q3C limits	Validated by GC headspace analysis
Solubility	Soluble in DMF, DMSO, THF; slightly soluble in methanol	Standard solubility for Fmoc-amino acids in coupling solvents
Melting point	170–175 °C (decomposition)	Determined by differential scanning calorimetry (DSC)
Storage conditions	2–8 °C, sealed, protected from light	Stable for 36 months under these conditions
Packaging	25 g, 100 g, 500 g, 1 kg, 25 kg	Custom packaging available under inert gas on request
Documentation	COA, MSDS, TDS, solubility certificate	Additional quality documents can be supplied after purchase order

Applicable Scenarios

Academic laboratories performing Fmoc solid-phase peptide synthesis use Fmoc-Gly-OH as the C-terminal glycine building block to achieve efficient coupling without side-chain complications.
Process chemists at CDMOs developing generic peptide drugs depend on low-impurity Fmoc-Gly-OH to maintain reproducible reaction kinetics and meet regulatory filing requirements.
Manufacturers of cosmetic peptides, such as acetyl hexapeptide-8 and copper peptides, prefer this grade for reliable batch-to-batch consistency in short-sequence production.
Specialty biochemical distributors stock this Fmoc-Gly-OH in bulk quantities to serve secondary repackaging needs for diagnostic and immunoassay reagent producers.
Radiopharmaceutical research groups require certified residual solvent data and traceable COAs to support synthesizer kits used in clinical trial isotope labeling.

Common FAQs

Where can I find a reliable Fmoc-Gly-OH supplier in China?

Baishixing offers Fmoc-Gly-OH with purity ≥99% by HPLC and full COA. Supply capacities range from tens of grams to hundreds of kilograms. Contact their technical support for specific packaging and lead times.

What is the CAS number for Fmoc-Gly-OH?

The CAS number is 29022-11-3. This registry number is used for ordering, customs declaration, and database searches relating to Fmoc-glycine.

Can Fmoc-Gly-OH be used for solid-phase peptide synthesis?

Yes. It is a standard Fmoc-protected amino acid designed for SPPS. The carboxyl group reacts with resin-bound amines, and the Fmoc group is removed under piperidine conditions. Conduct a Kaiser test to verify coupling efficiency.

How should Fmoc-Gly-OH be stored?

Store it in a tightly sealed container, away from sunlight and moisture. For long-term stability, keep the material at 2–8 °C. Under these conditions, it remains stable for at least 36 months.

What purity levels are available?

Standard purity is ≥99.0% as determined by HPLC. Each lot is also checked for water content and residual solvents. Custom purity profiles or additional impurity analysis can be arranged upon request.

Does Fmoc-Gly-OH require cold-chain transport?

In sealed packages, normal shipping is acceptable if the temperature stays below 30 °C for a few days. For larger quantities or warm climates, insulated packaging with cooling elements can be provided.

What is the molecular weight of Fmoc-Gly-OH?

The molecular weight is 297.31 g/mol, calculated from the formula C₁₇H₁₅NO₄. Use this value for molar equivalent calculations when preparing resin loading or coupling stoichiometry.

Is a certificate of analysis provided with each shipment?

Yes, every batch ships with a COA that lists the HPLC purity, water content, loss on drying, appearance, and residual solvent values. The COA also includes the batch number and production date.

Differentiation Summary

Unlike many distributors who repackage generic Fmoc-Gly-OH without deep process control, Baishixing directly coordinates manufacturing with documented quality control and flexible batch sizing. The combination of strict ICH-residual solvent compliance, complete COA reporting, and stable scaling keeps consistent purity from kilogram to tonnage orders. This makes Baishixing’s Fmoc-Gly-OH a practical choice for both academic researchers and pharmaceutical companies that require supply security and regulatory documentation without compromising on raw material transparency.