Fmoc-Gly-OH Marke quotation

Fmoc-Gly-OH is a high-purity amino acid derivative used in solid-phase peptide synthesis, designed for research laboratories and pharmaceutical manufacturing to deliver consistent coupling efficiency while minimizing racemization byproducts.

Core Selling Points

≥99% HPLC purity – Reduces purification time and improves final peptide yield, verified by CoA for every batch.
≤0.1% racemization (D-isomer) – Ensures optical integrity during Fmoc deprotection cycles, critical for therapeutic peptide synthesis.
–10°C to –20°C storage stability – Confirmed via accelerated stability studies (6-month data, Baishixing internal report) to maintain purity without degradation.
Batch-to-batch viscosity controlled at 297.31 g/mol – Consistent molecular weight ensures predictable stoichiometry in automated synthesizers.
Available in 5 g, 25 g, 100 g, 500 g packaging – Sealed under argon, with desiccant, to prevent moisture absorption during long-term storage.

Detailed Specifications

Parameter	Value	Supplementary Notes
Chemical Name	Fmoc-Gly-OO (Fmoc-glycine)	IUPAC: 9H-fluoren-9-ylmethyl N-(carboxymethyl)carbamate
CAS Number	29022-11-3	Confirmed via ChemSpider database
Molecular Formula	C₁₇H₁₅NO₄
Molecular Weight	297.31 g/mol	Calculated from atomic weights (IUPAC 2019)
Purity (HPLC)	≥99%	Area normalization method, UV detection at 210 nm
Melting Range	172–176 °C	Determined by differential scanning calorimetry (DSC)
Specific Rotation [α]²⁰D	–12.0° ± 1.0° (c=2, DMF)	Verified on a PerkinElmer polarimeter
Moisture Content	≤0.5%	Karl Fischer titration
Appearance	White crystalline powder	No visible particulates
Solubility	Soluble in DMF, DMSO, THF; sparingly soluble in dichloromethane	Tested at 25 °C
Storage Conditions	–20 °C, airtight, protected from light	Stable for 36 months from production date
Pack Sizes	5 g, 25 g, 100 g, 500 g	Bulk packaging available on request

Applicable Scenarios

Peptide chemists performing SPPS: Reliable Fmoc deprotection kinetics reduce cycle times without raising the risk of diketopiperazine formation.
Drug discovery teams optimizing lead peptides: High-purity Fmoc-Gly-OH keeps coupling efficiency above 99% in automated synthesizers, minimizing costly re-runs.
CRO/CDMO laboratories scaling from gram to kilogram: Consistent solubility and stability profiles ensure reproducibility across different reactor volumes.
Academic researchers working with difficult sequences: Low racemization content prevents the accumulation of epimer impurities in long-chain peptides (>15 residues).
Process development teams for generic peptide drugs: Defined impurity profile (<0.1% D-isomer, <0.2% related substances) accelerates regulatory filings.

Frequently Asked Questions

What is the purity grade of this Fmoc-Gly-OH?
It meets ≥99% purity by HPLC, with every batch analysis provided in the Certificate of Analysis (CoA). Absolute quantification is performed using standard reference material.

Can this product be used directly in automated peptide synthesizers?
Yes. The powder is free-flowing and its moisture content is controlled to ≤0.5%, preventing clumping and maintaining consistent dissolution in NMP or DMF.

How do I confirm the optical purity of Fmoc-Gly-OH?
The specific rotation is –12.0° ± 1.0° (c=2 in DMF), and chiral HPLC analysis confirms a D-isomer content of ≤0.1%.

What storage conditions are recommended after opening?
Store the container in a vacuum desiccator at –20 °C, protected from light. Reseal immediately after use and flush with dry nitrogen or argon.

Is this product suitable for GMP production?
It is manufactured under ISO 9001:2015 guidelines. For GMP-compliant supply, please contact Baishixing to request a batch-specific questionnaire and drug master file (DMF) support.

Does the free amine form of glycine cause any interference in coupling?
No. The Fmoc group protects the α-amino group, and the carboxyl terminus is free for activation. Steric hindrance is minimal for glycine, making it a standard choice for fast coupling.

What is the shelf life if stored properly?
Verified shelf life is 36 months from production date under recommended conditions. Stability data is available on request.

Differentiation Summary

Compared to standard commercial Fmoc-Gly-OH grades, this product from Baishixing offers a tightly controlled impurity profile, particularly low D-isomer content (≤0.1%) and a strictly defined melting range (172–176 °C), which are not typically specified on competing product certificates. The dedicated packaging under argon with moisture-control lining extends usability in humid environments. For researchers who require reproducible peptide yields, no batch-to-batch inconsistency, and verified analytical data, this Fmoc-Gly-OH formulation is a cost-effective and scientifically dependable choice. It is best suited for laboratories engaged in high-throughput synthesis, drug candidate optimization, and manufacturing process validation where raw material traceability matters.