Fmoc-Gly-OH Partners, long-termCooperation

Product Overview

Fmoc-Gly-OH (N-fluorenylmethoxycarbonyl-glycine) is a protected amino acid derivative specifically developed for solid-phase peptide synthesis, serving research laboratories and cGMP manufacturing facilities that require a consistent, high-purity building block with traceable quality and reliable long-term supply.

Core Selling Points

Purity ≥99% (HPLC, area%): Minimizes impurity carryover into the peptide chain, reducing the need for additional purification steps and improving overall crude peptide yield.
Batch-to-batch consistency within ±0.5% (HPLC): Each batch is supplied with a Certificate of Analysis (COA) and an HPLC chromatogram, allowing process scientists to reproduce synthesis results without process re-optimization.
Low chloride content ≤100 ppm: Meets the typical residual impurity threshold for peptide drug intermediates, simplifying downstream removal and facilitating regulatory submission for GMP use.
Stable shelf life of 24 months at 2–8 °C: Allows purchasing departments to maintain safe inventory levels without frequent re-ordering, supporting stable production planning and cost management.
Available in research to pilot quantities (10 g to 100 kg): Scales directly from early-stage discovery to late-stage process validation, reducing the risk of supplier switching during development.

Detailed Specifications

Parameter	Value	Supplementary Notes
Product Name	Fmoc-Gly-OH	N-fluorenylmethoxycarbonyl-glycine
CAS Number	29022-11-3	Unique identifier for the compound
Molecular Formula	C₁₇H₁₅NO₄	Calculated from the structure
Molecular Weight	297.31 g/mol	Average molecular mass
Purity	≥99% (HPLC, area%)	Measured at 254 nm
Appearance	White crystalline powder	No visible contamination
Optical Rotation	[α]₂₀ᴰ 0° ± 2° (c=1, DMF)	Glycine is achiral, but confirmation is performed per specification
Loss on Drying	≤0.5%	Determined after 3 h at 60 °C
Chloride Content	≤100 ppm	Determined by ion chromatography
Heavy Metals	≤10 ppm	Measured by ICP-MS
Residual Solvents	≤5000 ppm (ethanol, acetonitrile)	Complies with ICH Q3C thresholds
Storage Conditions	2–8 °C, sealed, dry, away from light	Do not expose to strong acids or bases
Shelf Life	24 months from date of manufacture	With valid COA and stability data

Application Scenarios

Peptide R&D laboratories developing new therapeutic peptides and using Fmoc-based solid-phase synthesis protocols benefit from consistent coupling efficiency, which directly reduces trial-and-error time in sequence optimization.
Contract Development and Manufacturing Organizations (CDMOs) producing peptide APIs for clinical trials require raw materials with full traceability and low residual impurity profiles; this product meets both needs.
Research institutes studying peptide libraries for drug screening need a cost-effective building block that can be used in high-throughput parallel synthesis without batch variation.
Biotech companies scaling up from grams to kilograms prefer a supplier that can provide the same lot quality across multiple quantities, enabling smooth process scale-up without revalidation.
Procurement departments looking for a reliable long-term vendor value a consistent supply chain with documented stability and transparent quality data for audit purposes.

Common Questions

What is the CAS number of Fmoc-Gly-OH?

The CAS number is 29022-11-3; this identifier is used in chemical databases and regulatory documentation to unambiguously confirm the compound identity.

What purity grade is suitable for GMP peptide manufacturing?

For GMP use, a purity of at least 99% (HPLC) and a low chloride content (≤100 ppm) are recommended; this product meets both criteria and is supplied with a full COA.

Can Fmoc-Gly-OH be used in manual peptide synthesis?

Yes. It is compatible with standard Fmoc solid-phase protocols using DMF or NMP as solvents and common coupling reagents such as HBTU, HATU, or DIC.

Does Fmoc-Gly-OH require cold chain shipping?

No, cold chain shipping is not required if the product remains sealed and at controlled room temperature during transit. However, long-term storage must remain at 2–8 °C.

Is this product available in custom packaging sizes?

Yes, we offer sizes from 10 g research packs to 100 kg composite drums. Packaging materials (aluminum foil, HDPE, or fluorinated containers) can be customized upon request.

How is batch-to-batch consistency verified?

Every batch is tested for HPLC purity, water content, chloride, and heavy metals. A representative chromatogram is provided with the COA, and retained samples are available for 5 years.

What documentation is provided with each shipment?

Each shipment includes a Certificate of Analysis, a Material Safety Data Sheet (MSDS), and a batch-specific HPLC chromatogram. Additional documents such as stability summaries are available on request.

Who can benefit from long-term cooperation agreements?

Pharmaceutical companies, CDMOs, and research institutions that plan sustained peptide development programs benefit most from fixed pricing, guaranteed supply, and prior quality alignment.

Differentiation Summary

Compared to standard reagent supply channels, Fmoc-Gly-OH from Baishixing stands out in two ways: the robust documentation package and the scalable supply framework. While several chemical vendors offer similar purity levels, their batch documentation may be incomplete or their production scale may not match development timelines. This product is produced under ISO 9001:2015 quality management, and the supplier maintains a dedicated peptide-building-block production line, allowing for low impurity levels and flexible lot sizes. The intended user is a professional scientist or purchasing manager who prioritizes data integrity, regulatory readiness, and supply security over the lowest single-unit price. For those seeking a long-term partnership with predictable quality and stable logistics, this Fmoc-Gly-OH offering is a practical choice.