Fmoc-Gly-OH 29022-11-5 Supplier

1. Definition

Fmoc-Gly-OH (Fmoc-glycine) is a high-purity amino acid derivative used as a fundamental building block in solid-phase peptide synthesis (SPPS), supplied by Baishixing for research and pharmaceutical manufacturing applications.

2. Core Selling Points

Purity ≥ 98.5% (HPLC): Reduces by-product formation during peptide chain elongation, improving final product yield and eliminating additional purification steps
Optical purity ≥ 98.0%: Prevents racemization-related side reactions that can compromise peptide biological activity
Melting point range 174–178°C: Provides batch-to-batch consistency verification and reliable quality control parameter for incoming inspection
Solubility in DMF ≥ 100 mg/mL: Enables efficient coupling reactions at standard concentration protocols (0.1–0.3 M) without extended dissolution time
Documented impurity profile: Limits for acetic acid (< 0.5%) and moisture (< 1.0%) ensure predictable reactivity and extended storage stability

3. Detailed Parameter Table

Parameter	Value	Specification
Product Name	Fmoc-Gly-OH	Fmoc-glycine, N-α-Fmoc-glycine
CAS Number	29022-11-3	Chemical Abstracts registry identifier
Molecular Formula	C₁₇H₁₅NO₄	Confirmed by mass spectrometry
Molecular Weight	297.31 g/mol	Calculated from atomic weights
Purity (HPLC)	≥ 98.5%	Area normalization method
Optical Purity	≥ 98.0%	Chiral HPLC analysis
Appearance	White to off-white powder	Visual inspection
Melting Point	174–178°C	Differential scanning calorimetry
Loss on Drying	≤ 1.0%	Gravimetric analysis
Heavy Metals	≤ 10 ppm	ICP-MS analysis
Storage Conditions	2–8°C, sealed, dry	Under inert gas recommended
Shelf Life	12 months	Under specified storage conditions

4. Application Scenarios

Research institutions: Peptide chemistry laboratories use Fmoc-Gly-OH for synthesizing custom peptides for structure-activity relationship studies, enabling precise control over coupling efficiency in automated synthesizers
Pharmaceutical R&D: Drug discovery teams incorporate Fmoc-Gly-OH into lead compound optimization, producing peptide-based drug candidates with reproducible quality across batches
Contract manufacturing: CROs and CDMOs integrate this material into large-scale SPPS workflows, achieving consistent yields because the low impurity content prevents cumulative side reactions
Biotechnology: Diagnostic reagent manufacturers use Fmoc-Gly-OH to prepare defined peptide sequences for antibody production, obtaining specific immunogens without cross-reactive contaminants
Academic teaching: University chemistry departments standardize peptide synthesis practical courses with this reagent, helping students obtain expected products with predictable reaction behavior

5. Common Questions

What is Fmoc-Gly-OH used for?It is used as a protected glycine building block in solid-phase peptide synthesis, where the Fmoc group temporarily protects the amino group during chain assembly.

What is the difference between Fmoc-Gly-OH and Boc-Gly-OH?Fmoc-Gly-OH uses base-labile Fmoc deprotection, while Boc-Gly-OH requires acid cleavage. Fmoc chemistry works under milder conditions, making it suitable for sensitive peptides.

How should Fmoc-Gly-OH be stored to maintain purity?Store at 2–8°C in a tightly sealed container away from moisture and light. Bring to room temperature before opening to prevent condensation.

What purity level is required for SPPS applications?Purity above 98.5% is recommended to avoid accumulation of deletion peptides. The actual requirement depends on the target peptide length and application.

Is Fmoc-Gly-OH soluble in common organic solvents?Yes, it dissolves readily in DMF, DMSO, and NMP at concentrations suitable for standard peptide coupling protocols.

Does Baishixing provide analytical data with each batch?Each delivery includes COA (Certificate of Analysis) showing HPLC purity, optical purity, and residual solvent data. Batch-specific retain samples are available.

6. Differentiation Summary

Fmoc-Gly-OH from Baishixing distinguishes itself from standard commercial offerings through consistently low optical impurity levels (< 2.0%) and comprehensive heavy metal documentation (≤ 10 ppm). The reagent performs effectively in automated peptide synthesizers, where manufacturers identify batch consistency in solubility and coupling kinetics as having a positive impact on production throughput. While multiple chemical suppliers offer Fmoc-glycine, a more rigorous purity specification process here provides laboratories and manufacturers that require traceable quality data a reliable option. We recommend this product for research groups working on longer peptides (more than 20 residues) or production teams requiring documented, reproducible peptide purity across large-volume runs. Peptide synthesis applications that can accept broader specification limits may find alternative grades to be more cost-effective.