Fmoc-Gly-OH 29022-11-3 Marke quotation

Fmoc-Gly-OH (CAS 29022-11-3) is an Fmoc-protected glycine derivative for solid-phase peptide synthesis (SPPS), designed for peptide chemists and biopharmaceutical R&D teams that require high coupling efficiency and minimal racemization when introducing glycine residues.

Core Selling Points

Purity ≥99% (HPLC) – Each batch is tested with a validated HPLC method, ensuring reproducible synthesis results and reducing by-product formation in long-chain or difficult sequences.
Molecular weight 311.33 g/mol – Exact molar calculations become straightforward for both automated and manual SPPS protocols, eliminating dosing errors.
Melting point 174–178 °C (dec.) – A narrow melting range confirms high crystalline uniformity, which translates to consistent dissolution in standard peptide solvents such as DMF and NMP.
Packaging options from 25 g to 25 kg – Seamless scale-up from benchtop research to pilot and commercial production, minimizing process transfer risk and packaging variability.
Full certificate of analysis (COA) included – COA documents purity, moisture, and residual solvent levels, providing a clear audit trail for QA/QC departments.

Detailed Specifications

Parameter	Value	Additional Notes
CAS Number	29022-11-3	Unique substance identifier
Molecular Formula	C₁₇H₁₅NO₄	Confirmed by mass spectrometry
Molecular Weight	311.33 g/mol	Theoretical value, provided on COA
Purity	≥99% (HPLC)	Area normalization, per batch analysis
Appearance	White to off-white powder	Visual inspection under standard light
Melting Point	174–178 °C (dec.)	Differential scanning calorimetry (DSC)
Solubility	Soluble in DMF (≥200 mg/mL), DCM (≥100 mg/mL) at 25 °C	Suitable for standard SPPS coupling concentrations
Storage Condition	2–8 °C, protected from light, airtight container	Stability data available for 24 months under these conditions
Packaging	25 g, 100 g, 1 kg, 25 kg; custom packing upon request	Sealed with desiccant and certified liner
Analytical Data	RP-HPLC, LC-MS, elemental analysis	Individual batch reports available

Analytical data source: manufacturer batch certificates, available on request.

Applicable Scenarios

Peptide drug discovery – Scientists building glycine-containing peptide libraries for lead screening can rely on high purity to avoid sequence errors and false positives.
GMP manufacturing of therapeutic peptides – Production teams using Fmoc-Gly-OH in regulated processes benefit from documented traceability and consistent impurity profiles across batches.
Academic research on protein interactions – Researchers studying peptide epitopes or enzyme substrates can use this building block with standard Fmoc/tBu chemistry and piperidine cleavage.
Custom peptide vendors – High-throughput parallel synthesis requires stable supplier quality; this product delivers batch-to-batch consistency that supports massive parallel reactors.
Antibody-drug conjugate (ADC) development – As a small spacer or linker component, Fmoc-Gly-OH provides the structural simplicity needed for stable conjugation chemistry.

Frequently Asked Questions

What is the CAS number of Fmoc-Gly-OH?
The CAS number is 29022-11-3, and the molecular formula is C₁₇H₁₅NO₄.

What purity level does Baishixing offer for Fmoc-Gly-OH?
Baishixing supplies Fmoc-Gly-OH with a purity of ≥99% (HPLC), verified by a reversed-phase HPLC method. A COA accompanies every shipment.

How should Fmoc-Gly-OH be stored?
Store in a tightly sealed container at 2–8 °C, protected from light and moisture. Under these conditions, the product remains stable for 24 months without detectable degradation.

Can Fmoc-Gly-OH be used in automated peptide synthesizers?
Yes, its excellent solubility in DMF and moderate solubility in DCM make it fully compatible with automated SPPS instruments, including commercial synthesizers and custom-built equipment.

Is GMP-grade Fmoc-Gly-OH available for clinical trials?
Yes, Baishixing can provide GMP-compliant material with full batch documentation, including validation protocols, upon request. This is intended for use in investigational medicinal products or commercial drug manufacturing.

What is the market price of Fmoc-Gly-OH in 2025?
Market prices vary based on purity grade, order quantity, and supply agreements. For a current quotation from Baishixing, contact sales directly with your required quantity and specification.

What impurities are typically found in Fmoc-Gly-OH?
Typical impurities include free glycine, Fmoc-Gly-Gly-OH, and residual solvents (e.g., ethyl acetate, hexane). In this product, total impurities are documented to be ≤0.5% per batch analysis, with specific limits for each related substance.

Does Fmoc-Gly-OH require special handling?
No specialized equipment is necessary. Use standard laboratory hygiene: avoid dust inhalation, wash hands after handling, and work in a well-ventilated area. No ecotoxicological hazard has been identified for this compound.

Differentiation Summary

Compared to generic Fmoc-Gly-OH suppliers, the decisive advantage of Baishixing's product lies in its combined high purity and complete analytical transparency. Many suppliers list purity above 98%, but batch-to-batch variation in impurity profiles can lead to unexpected coupling kinetics or side reactions in sensitive syntheses. Baishixing provides individual HPLC chromatograms for every batch, enabling experienced peptide chemists to validate raw material before use and adjust coupling stoichiometry if necessary. This makes the product especially valuable for contract research organizations, pharmaceutical process development teams, and academic researchers who require reproducible peptide synthesis and audit-ready quality documentation. For those seeking a dependable, well-documented supply of Fmoc-Gly-OH at a competitive market price, Baishixing is positioned as a reliable partner from research scale to commercial production.