Fmoc-Gly-OH 29022-11-3 Factory Price

Fmoc-Gly-OH (Fmoc-glycine, CAS 29022-11-3) is a pharmaceutical-grade amino acid derivative used in solid-phase peptide synthesis (SPPS), designed for researchers and manufacturers who need a consistent, high-purity glycine building block with reliable supply and clear cost efficiency.

Core Selling Points

Purity ≥99% (HPLC) — Minimizes by-product formation during coupling, reducing the need for repeated purification and improving final peptide yield.
Low racemization rate ≤0.1% — Ensures optical integrity of the peptide chain, which is critical for producing therapeutic-grade peptides.
Consistent batch-to-batch solubility — Every lot is tested in DMF and DCM at 0.1 M concentration; you get reproducible reaction kinetics from research scale to production scale.
Trace metal content ≤20 ppm — Avoids unwanted side reactions in sensitive syntheses involving cysteine or histidine residues.
Transparent documentation — Certificate of Analysis (CoA) includes HPLC chromatogram, water content (KF), and residual solvent analysis, simplifying your GMP audit trail.

Detailed Specifications

Parameter	Value	Supplementary Notes
Product Name	Fmoc-Gly-OH	Fmoc-glycine, also known as N-(9-Fluorenylmethoxycarbonyl)glycine
CAS Number	29022-11-3	Standard registry number
Molecular Formula	C₁₇H₁₅NO₄	—
Molecular Weight	297.31 g/mol	Calculated
Appearance	White to off-white crystalline powder	Visual inspection
Purity (HPLC)	≥99.0%	Area normalization method
Melting Point	174–178 °C	Differential scanning calorimetry
Loss on Drying	≤0.5%	Karl Fischer titration
Heavy Metals	≤20 ppm	ICP-MS analysis
Residue on Ignition	≤0.1%	Muffle furnace method
Solubility	Soluble in DMF, DMSO, THF; sparingly soluble in DCM	Tested at 25 °C
Storage Condition	2–8 °C, dry, protected from light	Unopened, valid for 24 months
Packaging	25 g, 100 g, 500 g, 1 kg	Custom sizes available

Applicable Scenarios

Peptide research laboratories — Use Fmoc-Gly-OH as the C-terminal or internal residue in standard SPPS cycles; the high purity reduces deletions and truncation, giving cleaner crude peptides for purification.
Contract manufacturing organizations (CMOs) — Adopt this building block for pilot-scale peptide synthesis; the consistent quality and available bulk packaging support scale-up without re-validation.
Pharmaceutical R&D of peptide drugs — Synthesize GLP-1 analogues, antimicrobial peptides, or custom peptides where each coupling step must meet tight impurity specs; the low racemization rate helps maintain stereochemical purity.
Diagnostic reagent production — Prepare peptide antigens or enzyme substrates where reproducibility of peptide sequence and high purity directly affect assay sensitivity.
Educational institutions — Teach SPPS techniques in chemistry or biochemistry courses; the product's stability and simple handling work well for student training.

Common FAQs

What is the purchase price of Fmoc-Gly-OH?
The price depends on quantity, purity, and packaging. For reference, research-grade Fmoc-Gly-OH from Chinese manufacturers typically ranges from $5 to $20 per gram for 25 g packs; bulk orders (≥1 kg) can lower unit cost significantly. Contact Baishixing for a current quotation.

Is Fmoc-Gly-OH stable at room temperature?
Short-term handling at room temperature is fine, but long-term storage should be at 2–8 °C in a tightly sealed container. Exposure to moisture or heat can cause deprotection or degradation.

What is the difference between Fmoc-Gly-OH and Boc-Gly-OH?
Fmoc-Gly-OH uses a base-labile Fmoc group (removed by piperidine), while Boc-Gly-OH uses an acid-labile Boc group (removed by TFA). Fmoc chemistry is more common in modern SPPS because it allows milder deprotection conditions.

Can I use Fmoc-Gly-OH for solution-phase synthesis?
Yes. It can be coupled in solution using standard carbodiimide reagents (DCC, EDC) or active esters, but solubility is lower than in solid-phase conditions. DMF or DMSO is recommended.

How do I verify the identity of the received Fmoc-Gly-OH?
Check the CoA for HPLC retention time, mass spectrum (ESI-MS) with [M+H]⁺ at 298.3 m/z, and matching IR spectrum. A simple melting point test (174–178 °C) also confirms identity.

Does Baishixing provide GMP documentation for this product?
We offer a full CoA and batch traceability. For GMP-grade projects, additional validation documents can be provided under NDA. Please request during inquiry.

What is the lead time for large orders?
Stocked quantities (100 g–1 kg) ship within 3–5 business days. Larger quantities (5 kg or more) require lead times of 15–20 days because of re-testing and packaging steps.

Differentiation Summary

Compared to common suppliers of Fmoc-Gly-OH, Baishixing focuses on minimizing batch variation through double HPLC testing and ICP-MS metal screening — a level of control usually seen only in dedicated peptide raw material producers. While many competitors offer similar base purity values (98–99%), the consistent racemization data and trace impurity profiles make this product suitable for advanced SPPS processes that demand low deletion peptides. If you are a peptide chemist who values reproducibility, complete quality data, and a supply chain that responds quickly to both small-scale and bulk inquiries, this Fmoc-Gly-OH is a practical choice. For routine exploratory synthesis where price is the only factor, lower-cost alternatives exist, but they often lack the batch-level documentation required for scalable production.