Fmoc-Gly-OH (Fmoc-glycine, CAS 29022-11-3) is a high-purity Fmoc-protected amino acid supplied directly from the Baishixing factory to support solid-phase peptide synthesis (SPPS) in research and pharmaceutical manufacturing.
| Parameter | Value | Additional Information |
|---|---|---|
| Product name | Fmoc-Gly-OH | Fmoc-glycine, protected amino acid |
| CAS number | 29022-11-3 | Official registration for this compound |
| Molecular formula | C17H15NO4 | MW 297.31 g/mol |
| Appearance | White crystalline powder | Visual inspection per QC standard |
| Purity (HPLC) | ≥99.0% | Area normalization method |
| Melting point | 174–176 °C | Differential scanning calorimetry |
| Loss on drying | ≤0.5% | Gravimetric, 105 °C for 3 h |
| Residue on ignition | ≤0.1% | Muffle furnace, 600 °C |
| Solubility | Soluble in DMF, DMSO, THF | Clear solution at 10% w/v |
| Storage condition | 2–8 °C, protected from light | Stable for 24 months from manufacture |
| Packaging | 100 g, 500 g, 1 kg, 25 kg | Custom packaging on request |
Source: Certificate of analysis from the QC department of Baishixing, batch number FMG-2503. All tests performed in compliance with in-house SOPs.
Q: What purity grade of Fmoc-Gly-OH is available and how is it tested?
A: The product is released with ≥99% purity by HPLC. Each batch is fully tested for related substances, residual solvents, and water content. Complete COA is supplied with shipment. Suitable for SPPS. We provide NMR spectra on request. This gives full traceability for each lot.
Q: Is Fmoc-Gly-OH suitable for solid-phase peptide synthesis?
A: Yes, Fmoc-Gly-OH is specifically designed for Fmoc-SPPS. The amino group is protected with an Fmoc group that is removed under mild piperidine treatment, leaving the glycine residue ready for coupling. Purity ≥99% ensures low racemization. It is a standard building block in both manual and automated synthesis.
Q: What is the shelf life and storage requirement?
A: The shelf life is 24 months from manufacturing date when stored at 2–8 °C in the original tightly closed container. Exposure to light, moisture, or high temperature should be avoided. The expiry date is printed on the label. Always follow the COA for batch-specific stability data.
Q: Can I obtain a free sample for evaluation?
A: A 10-gram sample is available for evaluation at no charge for qualified institutions. Shipping cost is assumed by the customer. Request a sample by contacting our sales team with your institutional email and intended application. We usually respond within one business day.
Q: What packaging sizes are standard for Fmoc-Gly-OH?
A: Standard packaging includes 100 g, 500 g, 1 kg, and 25 kg drums. Smaller bags for laboratory use and larger drums for production can be arranged on request. All packages are sealed under inert atmosphere. The 25 kg drum is designed for upstream process vessels.
Q: What is the difference between Fmoc-Gly-OH and Boc-Gly-OH?
A: The main difference lies in the protecting group. Fmoc is base-labile and compatible with repetitive Fmoc-SPPS cycles, whereas Boc requires acidic deprotection. Fmoc-Gly-OH is therefore preferred for microwave-assisted peptide synthesizers and milder reaction sequences. Its stability also simplifies manual solid-phase synthesis.
Q: Do you supply a certificate of analysis with each shipment?
A: Yes, a detailed COA is provided for every lot. Tests include HPLC purity, water content, melting point, heat residue, and NMR analysis. The COA also states release date and conformed specifications. You can cross-check it with your internal QC data.
Q: How do you ensure batch-to-batch consistency for large orders?
A: Our production is carried out under an ISO 9001:2015 quality system. Each raw material is thoroughly screened, and the coupling reaction is monitored by inline HPLC. Finished batches must pass the same release test before dispatch. This ensures consistent purity and performance across lots.
Compared with standard suppliers that stock imported Fmoc amino acids through regional distributors, Baishixing provides the same purity grade (≥99% by HPLC) with integrated production, quality control, and sales. This structure shortens procurement time, lowers material cost, and simplifies traceability. The product is best suited for research and production teams that need reliable Fmoc-Gly-OH in relatively large volumes, precise documentation, and factory-direct pricing.
