Bulk Supply Fmoc-Gly-OH 29022-11-5

Overview

Fmoc-Gly-OH (CAS 29022-11-3) is a high-purity Fmoc-protected glycine derivative manufactured by baishixing for peptide drug developers, CROs, and research laboratories that need consistent, traceable raw materials for solid-phase peptide synthesis (SPPS) at any scale.

Core Selling Points

Purity ≥ 99.0% (HPLC) — Each lot is released with full chromatographic data; impurity profiles are reported on the certificate of analysis, so quality control teams can verify batch-to-batch consistency before committing to production runs.
Molecular weight 297.31 g/mol, CAS 29022-11-3 — Chemical identity is confirmed by IR and mass spectrometry on every lot; documentation supports regulatory filings and downstream drug development dossiers.
Supply from 100 g to multi-hundred-kilogram quantities — Dedicated production lines handle small R&D orders and large commercial campaigns alike, without process revalidation between scale ranges.
Bulk packaging in 500 g, 1 kg, 5 kg, and 25 kg formats — Double polyethylene liners with nitrogen purge inside aluminum foil bags; custom particle size distribution is available for automated peptide synthesizers.
Full lot traceability — Every shipment includes COA, MSDS, and retest date; retention samples are preserved for 24 months for audit or dispute resolution purposes.

Detailed Specifications

Parameter	Value	Supplementary Notes
Product name	Fmoc-Gly-OH	Fmoc-glycine (9-fluorenylmethyloxycarbonyl-glycine)
CAS number	29022-11-3	Verified against certified reference materials
Molecular formula	C₁₇H₁₅NO₄
Molecular weight	297.31 g/mol	Per IUPAC standard atomic weights
Assay (HPLC)	≥ 99.0%	Area normalization method per EP 2.2.29
Appearance	White to off-white crystalline powder	Visual inspection, lot-by-lot
Melting point	174–179 °C	Determined by digital melting point apparatus
Loss on drying	≤ 0.5%	Gravimetric method, 105 °C for 3 hours
Heavy metals	≤ 10 ppm	ICP-MS method
Residue on ignition	≤ 0.1%	Tested per USP \<281>
Specific rotation	Not applicable	Glycine is achiral; no optical rotation expected
Solubility	Soluble in DMF and DMSO; slightly soluble in ethanol	Tested at 25 °C
Residual solvents	Report on COA	GC headspace method
Storage conditions	2–8 °C, protected from light and moisture	Shelf life: 24 months from manufacture date
Standard package sizes	500 g; 1 kg; 5 kg; 25 kg	Custom sizes available by request
Documentation	COA, MSDS, IR spectra, MS spectra	Additional data provided on request

Application Scenarios

Peptide API manufacturing — Process engineers at pharmaceutical companies sourcing Fmoc monomers for GMP-compliant SPPS of peptide drugs; consistent lot purity reduces deviation investigations and rework during process validation.
CRO/CMO custom synthesis projects — Project leaders managing multiple parallel synthesis campaigns need documented impurity data to accelerate method development; this product ships with the analytical package to support that workflow.
Academic and industrial research labs — Researchers running SPPS for peptide libraries or structure-activity studies benefit from DMF/DMSO solubility and clean coupling behavior on automated synthesizers.
Diagnostic reagent and assay kit production — Manufacturers producing peptide-based kits prefer single-lot sourcing at volume; this product supports batch consistency across multi-thousand-unit kit runs.
Process scale-up and registration — Development chemists migrating from laboratory to pilot scale rely on stable supply chains and technical documentation to support their scale-up reports and regulatory submissions.

Frequently Asked Questions

What is the CAS number for Fmoc-Gly-OH?The CAS registry number is 29022-11-3. The molecular formula is C₁₇H₁₅NO₄, and the molecular weight is 297.31 g/mol. Cross-check all three identifiers against your internal specifications before ordering.

What is the minimum purity guarantee?Every lot is released at ≥ 99.0% purity by HPLC area normalization. The certificate of analysis lists the exact assay value, related substance peaks, and residual solvent data. No material ships below this threshold.

How should Fmoc-Gly-OH be stored?Store in a tightly closed container at 2–8 °C, away from light and moisture. Under recommended conditions, the product meets specifications for 24 months from the date of manufacture. Avoid prolonged exposure to temperatures above 25 °C.

Does baishixing provide a certificate of analysis with every order?Yes. Each shipment includes a COA covering assay (HPLC), appearance, melting point, loss on drying, heavy metals, and residual solvents. IR and mass spectra for the specific lot can be provided upon request.

What quantities are available for bulk supply?Standard packaging includes 500 g, 1 kg, 5 kg, and 25 kg units. Orders above 100 kg can be arranged with production scheduling lead times, and multi-hundred-kilogram commitments may qualify for dedicated batch allocation.

Is Fmoc-Gly-OH suitable for GMP production?This product meets analytical-grade criteria and ships with batch records, impurity profiles, and stability summaries. Your quality unit should perform a vendor assessment to confirm alignment with GMP requirements for your specific application.

What is the difference between Fmoc-Gly-OH and Boc-Gly-OH?Fmoc-Gly-OH carries a base-labile 9-fluorenylmethyloxycarbonyl group, while Boc-Gly-OH uses an acid-labile tert-butyloxycarbonyl group. They are used in different SPPS strategies — Fmoc/tBu chemistry versus Boc/Bzl chemistry — so the choice depends on your overall deprotection scheme.

Does Fmoc-Gly-OH work with automated peptide synthesizers?Yes. The product is a free-flowing crystalline powder, though we recommend verifying flow characteristics on your specific synthesizer deck. Custom particle size distribution can be manufactured on request to optimize dispensing performance.

Differentiation Summary

This product differs from commodity Fmoc-Gly-OH supplies in two ways: the analytical depth of its release documentation and the flexibility of its supply chain. Many vendors ship product with a single purity value and no supporting impurity data, which forces downstream labs to perform their own full characterization before use. Here, each lot arrives with complete chromatographic and spectroscopic documentation, allowing receiving QC to release the material immediately without lengthy in-house testing. The multi-tier packaging system also accommodates both small R&D orders and full-scale manufacturing campaigns without requiring a change in vendor or re-qualification of the raw material. Peptide manufacturers, CROs, and research groups that treat raw material consistency as a critical quality attribute will find this product aligned with their workflow requirements. Those needing only occasional gram-scale quantities may prefer a local distributor instead, but for any program that depends on reproducible peptide synthesis, the traceability and documentation built into this supply model offer practical advantages.