Fmoc-Gly-OH 29022-11-3 Powder Supplier

Fmoc-Gly-OH is a high-purity N-Fmoc-protected glycine derivative designed for solid-phase peptide synthesis (SPPS), providing researchers and pharmaceutical manufacturers with efficient coupling performance, minimal side reactions, and consistent batch-to-batch quality.

Key Features & Value

Purity ≥99.0% (HPLC) — Reduces by-product formation and shortens purification time, leading to higher final peptide yields.
Loss on drying ≤0.5% — Prevents premature Fmoc deprotection during storage or coupling, ensuring reproducible reaction outcomes.
Controlled particle size (80–200 µm) — Offers stable solubility and flow in DMF, critical for automated peptide synthesizers.
Low endotoxin level (≤0.25 EU/g) — Suitable for research and early-stage pharmaceutical peptide development where endotoxin control is required.
Batch-specific COA with full impurity profile — Provides traceability for investigations and regulatory submissions, simplifying quality assurance workflows.

Detailed Specifications

Parameter	Value	Supplementary Notes
Chemical Name	N-(9-Fluorenylmethoxycarbonyl)glycine
CAS Number	29022-11-3	Unique identifier for regulatory use
Molecular Formula	C₁₇H₁₅NO₄
Molecular Weight	297.31 g/mol
Purity (HPLC)	≥99.0%	Determined by reverse-phase HPLC
Appearance	White crystalline powder
Melting Point	174–178 °C (dec.)	Decomposition point
Loss on Drying	≤0.5%	Measured after 2 h at 60 °C
Residual Solvents	Conforms to ICH Q3C	Verified per batch
Solubility	Soluble in DMF, DMSO, THF	Typical working concentration: 0.2–0.5 M in DMF

Applications

Peptide drug discovery: Medicinal chemists use this protected amino acid to introduce glycine at precise positions in lead peptides, enabling rapid structure–activity relationship (SAR) exploration.
Long-chain peptide synthesis: Process chemists rely on its consistent purity for assembling peptides containing more than 30 residues, where reducing each side reaction is essential.
GMP-oriented manufacturing: The low endotoxin content and full documentation support the production of peptide active pharmaceutical ingredients (APIs) under GMP principles.
Academic research labs: Graduate students and postdoctoral researchers use it as a dependable building block for learning SPPS or generating custom peptide sequences.

FAQ

1. What is the CAS number of Fmoc-Gly-OH?
The CAS number is 29022-11-3. This identifier is essential for ordering, inventory documentation, and accessing safety data sheets.

2. How should Fmoc-Gly-OH be stored?
Store in a tightly closed container at 2–8 °C, protected from light and moisture. Avoid repeated exposure to warm conditions to prevent degradation.

3. Can Fmoc-Gly-OH be used in microwave-assisted SPPS?
Yes, it tolerates temperatures up to 70 °C in DMF without notable racemization. Use a 2–3 fold excess and short coupling cycles for best results.

4. What is the recommended coupling concentration?
A 0.2–0.5 M solution in DMF is standard. For difficult sequences or high resin loading, increase to 3–5 equivalents to ensure complete coupling.

5. Does this product contain residual bases or salts?
No. The purification process removes residual bases and salts. Each batch is tested for conductivity and endotoxins, with typical endotoxin levels below 0.25 EU/g.

6. Is Fmoc-Gly-OH suitable for GMP production?
Yes, when paired with the provided documentation (COA, MSDS, quality agreement), it is acceptable as a raw material for GMP-produced peptides. Contact technical support for qualification details.

7. What impurities are commonly present?
Typical impurities include free glycine, Fmoc-Gly-Gly, and trace residual solvents. Our specification limits each single impurity to ≤0.1% and total impurities to ≤1.0%.

8. Can it be used with automated peptide synthesizers?
Absolutely. The controlled particle size and consistent purity allow reliable dispensing and reproducible coupling cycles, which are critical for automated platforms.

Differentiation Summary

Compared with standard-grade Fmoc-Gly-OH, Baishixing’s product offers tighter purity specifications, lower endotoxin limits, and comprehensive batch documentation. While generic suppliers deliver acceptable-quality reagents, Baishixing focuses on minimizing batch-to-batch variability—a critical factor for scale-up and clinical-stage synthesis. This product is particularly suited for pharmaceutical R&D teams, CROs, and GMP-oriented manufacturing sites that require high consistency, full traceability, and regulatory compliance. For researchers who value reproducible results and strict quality control, this reagent provides a cost-effective alternative without compromising performance.