Fmoc-Gly-OH 29022-11-3 Manufacturer Wholesale

Overview

Fmoc-Gly-OH (Fmoc-glycine, CAS 29022-11-3) is a high-purity (≥ 99.0% HPLC) N-Fmoc-protected amino acid supplied in bulk quantities for solid-phase peptide synthesis, enabling pharmaceutical manufacturers, CDMOs, and research institutions to achieve consistent yield and low racemization across multi-kilogram production runs.

Core Selling Points

HPLC purity ≥ 99.0% (verified by per-batch COA with chromatogram) minimizes by-product formation during coupling steps, reducing downstream purification costs in large-scale peptide manufacturing.
Lot-to-lot purity variance within ± 0.5% ensures reproducible reaction kinetics across production batches, eliminating the need for re-optimization when scaling from R&D to manufacturing.
Racemization rate below 0.1% under standard activation conditions preserves the diastereomeric integrity of the final peptide sequence, protecting final API quality.
Moisture content ≤ 0.5% (Karl Fischer method) prevents premature Fmoc deprotection during storage, maintaining reactivity in high-humidity production environments.
Flexible bulk packaging (100 g to 10 kg, double-layer PE bag with aluminum foil pouch) supports both research-scale studies and cGMP manufacturing workflows, with custom drum options available.

Detailed Specifications

Parameter	Value	Notes
Product Name	Fmoc-Gly-OH	N-(9-Fluorenylmethoxycarbonyl)glycine
CAS Number	29022-11-3
Molecular Formula	C₁₇H₁₅NO₄
Molecular Weight	297.31 g/mol
Appearance	White to off-white crystalline powder	Visual inspection
Purity (HPLC)	≥ 99.0%	Area normalization, RP-HPLC
Melting Point	174–176 °C	Differential scanning calorimetry
Optical Rotation [α]²⁰D	−14.5° ± 1° (c = 1, DMF)	Single wavelength measurement
Loss on Drying	≤ 0.5%	105 °C, 3 hours
Solubility	≥ 100 mg/mL in DMF	Also soluble in DMSO and THF
Heavy Metals	≤ 10 ppm	ICP-MS analysis
Residual Solvents	≤ 500 ppm	GC-MS, conforms to ICH Q3C
Storage Condition	2–8 °C, protected from moisture and light	Inert gas blanket recommended
Packaging	100 g / 500 g / 1 kg / 5 kg / custom	Bulk fiber drums available
Documentation	COA, MSDS, TGA, IR, HPLC chromatogram	Provided per lot

Suitable Applications

Therapeutic peptide API manufacturing: Producing GLP-1 analogs, somatostatin, and other glycine-containing peptides in clinical and commercial quantities where uniform coupling efficiency is non-negotiable.
CDMO/cGMP production: Contract development organizations executing multi-step SPPS benefit from certified starting materials with complete traceability documentation for regulatory filing.
Drug discovery research: Academic and industrial laboratories synthesizing glycine-containing peptide candidates for SAR studies and hit-to-lead optimization.
Peptide library screening: High-throughput parallel synthesis workflows where consistent amino acid quality is critical for generating comparable biological data across replicates.
Bioconjugation development: Producing peptide–drug conjugates or peptide–carrier complexes where the glycine residue is coupled at the N-terminus to linker molecules.

FAQ

What is Fmoc-Gly-OH used for?Fmoc-Gly-OH is a protected glycine derivative used as a building block in Fmoc-based solid-phase peptide synthesis (SPPS) to introduce glycine residues at specified positions in peptide chains.

Is Fmoc-Gly-OH suitable for GMP production?Yes. Each batch ships with a full documentation package: COA, HPLC chromatogram, IR spectrum, TGA, and MSDS. Additional GMP support documents are available on request.

How should Fmoc-Gly-OH be stored?Store at 2–8 °C in the original sealed packaging, protected from moisture and direct light. Under these conditions, the product remains stable for 36 months.

How is batch-to-batch consistency controlled?Every production lot undergoes dual inspection — in-house HPLC analysis and independent third-party verification — with all data summarized in the batch-specific COA.

Can I request a small sample before committing to bulk volume?Yes. Trial samples from 10 g to 50 g are available on request. Volume-based pricing applies from 500 g upward.

Does Fmoc-Gly-OH show racemic impurity concerns?Optical rotation is controlled at −14.5° ± 1° (c = 1, DMF), and lot-specific LC-MS data confirm dimer and DL-impurity levels remain below 0.5%.

What delivery timeline applies to bulk orders?In-stock items ship within 3–5 business days. Custom production runs (e.g., non-standard packaging or specialized specifications) ship within 15–20 days.

What payment terms are accepted for bulk purchases?Standard terms are T/T or irrevocable L/C for orders above 1 kg. Net-30 terms may be arranged for established accounts after credit review.

What Sets This Product Apart

Most laboratory-grade Fmoc-Gly-OH suppliers emphasize single-batch purity, but that metric alone does not ensure manufacturing reliability. Baishixing has engineered this product around three production-critical parameters: cross-lot purity variance held within ± 0.5%, racemization under standard activation kept below 0.1%, and residual solvent profiles that conform to ICH Q3C limits. Each shipment includes complete analytical documentation, including third-party verification, giving quality assurance teams defensible data for regulatory submission and production planning. This makes the product the practical choice for peptide manufacturers, CDMOs, and research groups transitioning from small-scale synthesis to commercial manufacturing, where supply consistency matters as much as initial purity.