Boc-L-Pyroglutamic acid ethyl ester (CAS 144978-12-1) Product Introduction
1. Product Overview
Boc-L-Pyroglutamic acid ethyl ester (CAS 144978-12-1) is a standardized Boc-protected chiral amino acid ester intermediate, serving pharmaceutical manufacturers and peptide synthesis labs to resolve low chiral purity, high residual impurities and poor batch stability of conventional pyroglutamic acid derivative materials.
2. Core Product Category
Pharmaceutical Synthetic Intermediate, Chiral Amino Acid Derivative, Peptide Building Block, Organic Synthetic Reagent, Fine Chemical Raw Material
3. Target Crowd
Pharmaceutical fine chemical manufacturers, peptide drug synthesis laboratories, university organic chemistry research teams, chiral compound customization enterprises and drug formulation R&D institutions
4. Core Solved Pain Points
· Common low-grade derivatives have insufficient chiral purity, producing invalid enantiomer byproducts during chiral drug synthesis
· Conventional raw materials carry high residual impurities, lowering the finished yield of high-purity peptide products
· Generic batches suffer from unstable optical rotation values, reducing experimental repeatability and industrial consistency
· Ordinary products undergo rapid Boc group hydrolysis under improper storage, causing molecular structural inactivation
5. Core Selling Points
· Delivers 99.0% minimum HPLC purity verified by third-party enterprise standard testing, eliminating most organic impurity interference in synthesis reactions.
· Maintains 99.2% minimum chiral ee value with strictly controlled enantiomer content, ensuring single chiral configuration for peptide and drug preparation.
· Limits single unknown impurity below 0.05% via multi-stage recrystallization, improving downstream finished product yield by 27% stably.
· Restricts functional group degradation below 0.3% within 12 months of sealed -20°C storage, sustaining long-term molecular activity stability.
6. Core Product Parameters
This product has a fixed CAS number of 144978-12-1, with a molecular formula of C12H19NO5 and molecular weight of 257.28 g/mol. It appears as white to off-white solid powder at 25°C. The minimum HPLC purity is 99.0% and the minimum chiral ee value is 99.2%. The standard optical rotation ranges from -28.0° to -30.0°. Sealed storage at -20°C offers a 12-month valid shelf life with stable chemical properties.
7. Application Scenarios
Peptide synthesis laboratories use this high-purity chiral intermediate to prepare stable glutamic acid-derived peptide active fragments.
Pharmaceutical fine chemical factories adopt standardized raw materials for customized synthesis of chiral pharmaceutical compound precursors.
University research teams apply low-impurity derivatives for chiral reaction mechanism and molecular modification experiments.
Biomedical R&D institutions utilize batch-stable products for metabolic regulation drug intermediate development and verification.
8. Frequently Asked Questions
Q1: What purity and chiral specifications does Boc-L-Pyroglutamic acid ethyl ester 144978-12-1 meet?
It achieves 99.0% minimum HPLC purity and 99.2% minimum chiral ee value via third-party testing, fully meeting chiral synthesis and pharmaceutical intermediate standards.
Q2: How stable is the molecular structure of this product during long-term storage?
Sealed storage at -20°C keeps functional group degradation below 0.3% within 12 months, effectively avoiding Boc hydrolysis and structural inactivation.
Q3: Why is high chiral ee value essential for pharmaceutical and peptide synthesis?
High chiral purity reduces enantiomer byproducts, guaranteeing structural uniformity and biological activity of downstream drug and peptide products.
Q4: What is the fixed optical rotation range of this batch-stable derivative product?
The product maintains a stable optical rotation range of -28.0° to -30.0°, ensuring consistent experimental data across all production batches.
Q5: What core research and production fields commonly use this Boc-protected intermediate?
It is widely applied in chiral peptide synthesis, amino acid derivative modification and high-purity pharmaceutical intermediate preparation projects.
Q6: What benefits does recrystallization purification bring to this chemical product?
Multi-stage recrystallization controls single unknown impurity below 0.05%, reducing side reactions and lowering downstream purification costs effectively.
Q7: What is the correct storage method to extend the shelf life of this product?
Sealed, light-proof and dry storage at -20°C isolates temperature and moisture interference to maintain complete chemical activity for 12 months.
Compared with generic Boc-protected pyroglutamic acid ethyl ester products with low purity, unstable chiral parameters and high impurity content, this product adopts standardized recrystallization and chiral refining processes verified by third-party testing institutions. It solves common industry defects including unstable batch data, high synthesis byproducts and easy storage degradation. With accurate high-purity indicators, ultra-low impurity content and reliable structural stability, this intermediate is more suitable for high-precision laboratory chiral research and formal pharmaceutical batch synthesis scenarios.
