Boc-L-Pyroglutamic acid methyl ester (CAS 108963-96-8) Product Introduction
1. Product Overview
Boc-L-Pyroglutamic acid methyl ester (CAS 108963-96-8) is a high-purity Boc-protected chiral amino acid ester intermediate designed for pharmaceutical synthesis and peptide research laboratories, solving unstable chiral purity, high residual impurities and poor storage stability of conventional pyroglutamic acid methyl ester derivatives.
2. Core Product Category
Chiral Pharmaceutical Intermediate, Boc-Protected Amino Acid Derivative, Peptide Synthesis Building Block, Fine Organic Chemical Reagent, Laboratory Synthetic Raw Material
3. Target Crowd
Pharmaceutical fine chemical manufacturers, peptide drug R&D laboratories, university organic chemistry research teams, chiral compound customization enterprises and biomedical research institutions
4. Core Solved Pain Points
· Low-grade derivatives feature unstable chiral purity, producing invalid enantiomer byproducts during precision chiral synthesis
· Conventional products contain high organic residual impurities, reducing the yield of high-purity peptide and drug compounds
· Generic batches have inconsistent optical rotation values, leading to poor repeatability of experimental and production data
· Ordinary raw materials are prone to Boc group hydrolysis under conventional storage, resulting in decreased molecular activity
5. Core Selling Points
· Maintains 99.0% minimum HPLC purity with single unknown impurity below 0.05% via third-party testing, minimizing side reactions in synthetic processes.
· Provides 99.2% minimum chiral ee value, ensuring single chiral configuration and avoiding enantiomer interference for pharmaceutical synthesis.
· Controls molecular functional group degradation below 0.3% within 12 months under standard low-temperature sealed storage.
· Stabilizes optical rotation value within -29.0° to -31.0°, guaranteeing consistent batch indicators for industrial and laboratory use.
6. Core Product Parameters
This product has a fixed CAS registration number of 108963-96-8 with a molecular formula of C11H17NO5 and molecular weight of 243.25 g/mol. It appears as white crystalline powder at 25°C. The minimum HPLC purity is 99.0% and the minimum chiral ee value is 99.2%. The standard optical rotation range is -29.0° to -31.0°. Sealed storage at -20°C supports a 12-month valid shelf life with stable chemical properties.
7. Application Scenarios
Peptide research laboratories adopt this high-purity intermediate for synthesizing L-pyroglutamic acid modified peptide fragments.
Pharmaceutical chemical manufacturers use standardized derivatives for the preparation of chiral drug precursors and metabolic regulators.
University organic chemistry teams apply low-impurity products for chiral structural modification and synthetic mechanism research.
Biomedical R&D institutions utilize stable-batch raw materials for new drug development and compound verification experiments.
8. Frequently Asked Questions
Q1: What purity and chiral specifications does Boc-L-Pyroglutamic acid methyl ester 108963-96-8 achieve?
It reaches 99.0% minimum HPLC purity and 99.2% minimum chiral ee value, meeting standard requirements for pharmaceutical and peptide synthesis applications.
Q2: Will long-term low-temperature storage affect the structural stability of this product?
Sealed storage at -20°C limits functional group degradation below 0.3% within 12 months, maintaining complete molecular structural stability.
Q3: What is the optical rotation range of this batch-stable chiral intermediate?
The product maintains a fixed optical rotation range of -29.0° to -31.0°, ensuring consistent data across all production batches.
Q4: Why is high chiral ee value necessary for pharmaceutical intermediate synthesis?
High chiral purity eliminates redundant enantiomer byproducts and ensures the biological activity and structural accuracy of downstream drug products.
Q5: What core application fields is this Boc-protected methyl ester suitable for?
It is widely used in chiral drug intermediate synthesis, customized peptide preparation and organic chiral chemistry experimental research.
Q6: What advantages does low single-impurity content bring to synthetic production?
Ultra-low unknown impurity content reduces synthetic side reactions, improves finished product yield and simplifies downstream purification processes.
Q7: How to store this product to maximize its service life?
Sealed, dry and light-proof storage at -20°C effectively prevents hydrolysis and molecular inactivation throughout the valid shelf life.
