Storage Precautions for N6-Cbz-L-lysine
I. Environmental Condition Control
1. Temperature and Humidity
Store in a cool, dry place at 2–8°C (refrigerated conditions) to prevent decomposition or deterioration under high temperatures.
Maintain low humidity (relative humidity <60%) to avoid moisture absorption affecting stability.
For long-term storage, use a freezer (-20°C), but avoid repeated freeze-thaw cycles to prevent damage to crystal structure or degradation.
2. Light and Air Isolation
The compound is sensitive to light, especially ultraviolet light. Store in brown glass bottles or aluminum foil bags to minimize light exposure.
Seal containers tightly to 隔绝 (isolate) oxygen, preventing oxidation of amino or ester groups (Cbz groups may slowly decompose under aerobic conditions).
II. Packaging and Container Requirements
Packaging Materials: Use inert containers (glass, polypropylene plastic) and avoid direct contact with metals (iron, copper) to prevent metal ion-catalyzed degradation.
Subpackaging Principle: If used frequently, divide large packages into small portions to reduce opening times. Seal immediately after use and place desiccants (e.g., silica gel) if necessary.
III. Stability and Degradation Risks
1. Chemical Stability
The Cbz protecting group (benzyloxycarbonyl) of N6-Cbz-L-lysine may hydrolyze under acidic or alkaline conditions. Ensure storage at neutral pH and avoid mixing with strong acids/bases.
Prevent contact with strong oxidants or reductants to avoid damaging the amino acid structure or protecting groups.
2. Microbial Contamination
For biological or pharmaceutical use, maintain a clean storage environment and sterilize containers (e.g., UV irradiation) to prevent microbial growth and product spoilage.
IV. Safety and Compliance Management
Labeling: Clearly mark the container with the compound name, purity, batch number, storage conditions, and expiration date to avoid confusion.
Compliant Operations: If classified as a hazardous chemical, follow laboratory/industrial safety regulations and keep away from fire sources and flammable materials.
V. Pre-Use Inspection
Observe the appearance before use. Clumping, discoloration, or unusual odors may indicate deterioration—test purity before use.
When thawing frozen samples, slowly warm in an ice bath to avoid stability issues from rapid temperature changes.
Strict control of storage environment, packaging materials, and operational protocols effectively maintains the chemical stability of N6-Cbz-L-lysine and extends its shelf life.
