N6-Cbz-L-lysine has shown the following latest application progress in the pharmaceutical and food fields:
Pharmaceutical Field
Synthesis of peptide drugs: N6-Cbz-L-lysine can serve as a crucial intermediate in the synthesis of complex peptide and protein drugs. Its amino group is protected by the benzyloxycarbonyl group, which avoids unnecessary reactions during peptide synthesis and allows precise participation in peptide bond formation. This is instrumental in constructing polypeptides with specific sequences and functions, holding significant importance for the development of peptide drugs for treating various diseases.
Preparation of pharmaceutical intermediates: Through biocatalysis, certain derivatives of N6-Cbz-L-lysine, such as N6-Cbz-L-lysine benzyl ester hydrochloride, can be converted into pharmaceutical intermediates—for example, key intermediates of statin drugs. This provides essential raw materials for the synthesis of statins, helping to reduce drug production costs and improve production efficiency.
Improvement of cognitive function: Lysine-based drugs, including relevant derivatives of N6-Cbz-L-lysine, can regulate the synthesis, metabolism, and release of neurotransmitters, affecting synaptic function in the brain to improve cognitive function. They can also promote the expression of brain-derived neurotrophic factor (BDNF), thereby facilitating the growth and survival of neurons. These properties demonstrate promising application prospects in various cognitive impairments such as Alzheimer’s disease and mild cognitive impairment.
Food Field
Lysine is one of the essential amino acids for humans. N6-Cbz-L-lysine can be converted into L-lysine through deprotection and other reactions, enabling its application in the food field:
As a nutritional fortifier: It can be added to foods such as beverages, rice, flour, and canned products. This enhances the protein utilization rate of food, fortifies nutritional content, promotes growth and development, increases appetite, reduces diseases, and strengthens physical fitness. When used in canned products, it also has deodorizing and preservative effects.
Development of functional foods: Its related derivative, lysine ethyl ester, has unique physiological functions such as promoting fat oxidation and lowering cholesterol, making it suitable for developing functional foods and health supplements. Additionally, chelates formed by lysine hydrochloride and other trace elements can improve the absorption and utilization rate of trace elements, which also have broad application prospects.
