L-Tyrosine Disodium Salt technical documentation

1. Product Overview
L-Tyrosine Disodium Salt is the disodium salt form of L-tyrosine, an aromatic amino acid derivative. By converting the carboxyl and phenolic hydroxyl groups of L-tyrosine into sodium salt forms, the compound exhibits different physicochemical characteristics compared with free L-tyrosine, particularly in aqueous formulation systems.
The material is commonly supplied as an anhydrous salt or hydrate form and is used in biochemical research, cell culture media preparation, analytical studies, and specialty chemical formulations. 

2. Chemical Information
Item Specification
Product Name L-Tyrosine Disodium Salt
Synonyms Disodium L-tyrosinate; L-Tyrosine disodium salt
CAS No. 69847-45-6
Hydrate CAS No. 122666-87-9
Molecular Formula (anhydrous) C₉H₉NNa₂O₃
Molecular Weight (anhydrous) 225.16 g/mol
Molecular Formula (dihydrate) C₉H₁₃NNa₂O₅
Molecular Weight (dihydrate) 261.19 g/mol
Chemical Category Amino acid sodium salt derivative

3. Structural Characteristics
L-Tyrosine Disodium Salt retains the fundamental structure of L-tyrosine, consisting of:
An amino group (-NH₂) 
A carboxylate group converted into sodium salt form 
A phenolic aromatic ring 
A chiral α-carbon configuration 
The molecular structure provides both amino acid characteristics and ionic salt properties, allowing researchers to adjust formulation parameters such as solubility, pH, and ionic strength.
The IUPAC name for the anhydrous form is:
Disodium (2S)-2-amino-3-(4-oxidophenyl)propanoate. 

4. Physical and Chemical Properties
Appearance
Typical appearance:
White to cream powder 
Crystalline powder form 
Free-flowing solid material 
Specifications may vary depending on hydration state and supplier quality grade. 
Solubility
L-Tyrosine Disodium Salt generally shows improved water compatibility compared with free L-tyrosine due to its sodium salt structure.
Solubility characteristics are influenced by:
Hydration state 
Temperature 
Solution pH 
Ionic strength 
Buffer composition 
pH Characteristics
Typical aqueous solution pH:
Approximately pH 10.5–12.0 (depending on concentration and product grade) 
The alkaline nature is associated with the presence of sodium ions and deprotonated functional groups. 

5. Quality Specification Parameters
Common quality control items include:
Identity Testing
Infrared spectroscopy (IR) 
HPLC identification 
Chemical identification tests 
Purity Analysis
Typical analytical methods:
HPLC assay 
Titration analysis 
Optical rotation measurement 
Example specifications for research-grade materials include HPLC purity ≥97.5–98%. 
Water Content
Water content depends on whether the material is anhydrous or hydrated.
Typical ranges:
Anhydrous grades: controlled residual water content 
Hydrate grades: defined crystal water content 
Trace Impurity Control
Potential quality parameters include:
Heavy metals 
Residual solvents 
Microbial limits 
Endotoxin testing (for specific biotechnology grades) 
Some cell culture-related grades specify endotoxin limits and heavy metal limits. 

6. Application Areas
6.1 Cell Culture Media Components
L-Tyrosine Disodium Salt is widely used in research-grade cell culture formulations.
Application considerations include:
Amino acid balance optimization 
Media preparation flexibility 
Improved dissolution behavior compared with free amino acid forms 
It is used in some biotechnology workflows involving recombinant protein and cell culture research. 

6.2 Biochemical Research
The compound is used as a laboratory reagent in studies involving:
Amino acid chemistry 
Protein-related research 
Enzyme interaction studies 
Molecular analysis 
Its defined chemical structure allows reproducible experimental preparation.

6.3 Analytical Chemistry
Typical analytical applications include:
Reference materials 
Chromatographic studies 
Amino acid analysis 
Chemical derivatization research 
The compound can serve as a standardized amino acid derivative in laboratory methods.

6.4 Chemical Synthesis Research
The phenolic and amino acid functional groups make L-Tyrosine Disodium Salt a useful starting material for research involving:
Tyrosine derivatives 
Molecular modification studies 
Functional amino acid chemistry 

7. Storage and Handling Recommendations
Storage Conditions
Recommended storage practices:
Store in tightly sealed containers 
Protect from moisture 
Keep in cool and dry conditions 
Avoid prolonged exposure to high humidity 
Some commercial specifications note that the material may be hygroscopic and should be protected from moisture. 
Handling
Recommended laboratory practices:
Avoid unnecessary exposure to air 
Use clean and dry equipment 
Prevent contamination during sampling and weighing 

8. Packaging Forms
Common packaging options include:
Laboratory reagent bottles 
Aluminum foil bags 
Polymer-lined containers 
Bulk pharmaceutical or biotechnology packaging 
Packaging selection depends on:
Purity grade 
Application requirements 
Storage duration 
Moisture protection requirements 

9. Technical Advantages
Compared with free L-tyrosine, L-Tyrosine Disodium Salt provides:
Salt Form Stability
The sodium salt structure improves handling characteristics in aqueous preparation systems.
Formulation Flexibility
Suitable for applications requiring controlled ionic composition and alkaline conditions.
Research Compatibility
Available in analytical and biotechnology grades with controlled purity specifications.

10. Future Development Trends
Future technical development of L-Tyrosine Disodium Salt may focus on:
Advanced Bioprocessing
Optimized cell culture formulations 
High-density cell culture systems 
Biomanufacturing media development 
High-Purity Amino Acid Materials
Improved purification technologies 
Customized analytical standards 
Low-impurity specialty grades 
Sustainable Production
Bio-based amino acid manufacturing 
Fermentation process optimization 
Resource-efficient production routes 

Conclusion
L-Tyrosine Disodium Salt is a specialized amino acid derivative combining the biochemical characteristics of L-tyrosine with the formulation advantages of a sodium salt. Its controlled chemical structure, water compatibility, and adjustable physicochemical properties make it valuable in biotechnology research, analytical chemistry, and advanced chemical formulation systems.
With continued development in bioprocess technology and high-purity biochemical materials, L-Tyrosine Disodium Salt is expected to maintain an important role as a research and industrial-grade amino acid ingredient.