High quality Fmoc-Gly-OH Factory Direct Sales

1. What Is Fmoc-Gly-OH

Fmoc-Gly-OH (Fmoc-glycine) is a high-purity amino acid derivative with a 9-fluorenylmethyloxycarbonyl (Fmoc) protecting group, designed for solid-phase peptide synthesis (SPPS), offering researchers and pharmaceutical manufacturers a reliable building block that solves the problems of batch-to-batch inconsistency, high purification costs, and uncertain supply chains.

2. Core Selling Points

Purity ≥ 99% (HPLC): Minimizes the accumulation of deletion peptides during long-chain synthesis, delivering cleaner crude products and reducing the need for costly preparative HPLC purification.  
Optical Purity (Enantiomeric Excess) ≥ 99.5%: Prevents racemization during coupling reactions, ensuring correct stereochemistry in the final peptide, which is critical for drug efficacy and safety.  
Factory-Direct Supply from Baishixing: Fmoc-Gly-OH is manufactured in-house with a production capacity of 500 metric tons per year, ensuring stable inventory, shorter lead times (7–15 days for standard orders), and removal of intermediary markups.  
CAS 29022-11-3, Molecular Weight 297.31 g/mol: Fully characterized with a Certificate of Analysis (CoA) accompanying every batch, including specific rotation, water content (≤ 1.0%), and mass spectrometry data.  
Custom Packaging Available: Supplied in 100 g, 500 g, 1 kg, and 25 kg fiber drums with aluminum foil bags, with options for vacuum sealing or nitrogen purging for long-term stability.

3. Detailed Specifications

Parameter	Value	Additional Notes
Product Name	Fmoc-Gly-OH (Fmoc-glycine)	CAS Number: 29022-11-3
Molecular Formula	C₁₇H₁₅NO₄	Molecular Weight: 297.31 g/mol
Appearance	White to off-white crystalline powder	Visual inspection per batch
Purity (HPLC)	≥ 99.0%	Area normalization method, C18 column
Enantiomeric Purity	≥ 99.5% ee	Determined by chiral HPLC
Melting Point	172–176 °C	Differential scanning calorimetry
Loss on Drying	≤ 1.0%	60 °C, 3 hours, vacuum
Heavy Metals	≤ 10 ppm	ICP-MS analysis
Solubility	Soluble in DMF, DCM, THF	Insoluble in water
Storage Conditions	2–8 °C, dry, airtight	Stable for 24 months from manufacture date
Packaging Options	100 g / 500 g / 1 kg / 25 kg	Custom sizes available on request
Documentation	CoA, MSDS, HPLC chromatogram	Provided with every shipment

All specifications are verified by Baishixing's in-house quality control laboratory, which is ISO 9001:2015 certified.

4. Applicable Scenarios

Research Scientists in Academia: A graduate student synthesizing a library of glycine-containing peptides for a structure-activity relationship study uses Fmoc-Gly-OH with consistent purity from vial to vial, ensuring reproducible biological assay results.  
Contract Research Organizations (CROs): A CRO performing multi-step peptide synthesis for a client's lead optimization program relies on the high enantiomeric purity to avoid chiral impurity complications during scale-up.  
Pharmaceutical Manufacturing: A production chemist scaling up a peptide drug candidate requires Fmoc-Gly-OH in 25 kg quantities, with the factory-direct lead time fitting a tight production schedule and the batch-to-batch consistency meeting GMP-aligned process requirements.  
Peptide Kit Manufacturers: A company producing pre-weighed peptide synthesis kits includes Fmoc-Gly-OH single-use vials, where the nitrogen-purged packaging protects the reagent's quality during extended shelf storage in ambient conditions.  
Custom Peptide Suppliers: A supplier offering customized peptide synthesis services needs a cost-effective glycine derivative to remain competitive in pricing without compromising on final product purity, making factory-direct procurement a strategic advantage.

5. Frequently Asked Questions

What is the difference between Fmoc-Gly-OH and Boc-Gly-OH?
Fmoc-Gly-OH uses a base-labile Fmoc group removed by piperidine, while Boc-Gly-OH uses an acid-labile Boc group removed by TFA. Fmoc chemistry is milder and more common in modern SPPS.

How should Fmoc-Gly-OH be stored to maintain its quality?
Store at 2–8 °C in a tightly sealed container, protected from moisture and light. Under these conditions, the product remains stable for 24 months.

What is the solubility of Fmoc-Gly-OH in common solvents?
It is freely soluble in DMF (dimethylformamide) and DCM (dichloromethane). It shows limited solubility in THF and is insoluble in water.

Can Fmoc-Gly-OH be used for solution-phase peptide synthesis as well?
Yes. While it is optimized for solid-phase synthesis, the same product works in solution-phase coupling using standard reagents like HATU, HBTU, or DCC/HOBt.

What quality documentation is provided with each shipment?
Each batch ships with a Certificate of Analysis (CoA), an HPLC chromatogram, a mass spectrometry report, and the Material Safety Data Sheet (MSDS). Additional documents are available on request.

Does Baishixing offer GMP-grade Fmoc-Gly-OH?
Yes. GMP-grade material is manufactured under a separate quality system with enhanced documentation. Contact the sales team to discuss GMP requirements and audit support.

What is the typical lead time for a 25 kg order?
Standard lead time is 7–15 days from confirmed order to dispatch for standard specifications, depending on the destination and shipping method chosen. Custom specifications may require 20–30 days.

6. Differentiation Summary

Fmoc-Gly-OH from Baishixing addresses the two most common pain points in peptide synthesis procurement: quality inconsistency and supply chain friction. Unlike generic amino acid suppliers who resell materials from multiple origins, Baishixing operates a dedicated production line for Fmoc-protected amino acids, which gives full control over purity (≥ 99%), enantiomeric excess (≥ 99.5%), and traceability from raw material to finished product. For research groups and manufacturers who need verified quality, GMP-grade options, and reliable factory-direct logistics without distributor surcharges, this product delivers a transparent and cost-effective solution. It is particularly suited for projects with stringent impurity standards, including generic peptide drug development, regulated production environments, and multi-batch clinical trial manufacturing.