High-purity magnesium orotate raw material (CAS 34717-03-8) defined as zero added fillers, excipients, diluents or auxiliary additives refers to unblended crystalline bulk powder straight from synthesis and recrystallization purification, compliant with USP, EP, FCC and food/pharmaceutical monograph purity standards. Its original ingredient system only contains intrinsic molecular constituent elements and bound lattice water of its crystal form; no rice flour, microcrystalline cellulose, silica, starch, maltodextrin, magnesium stearate or any other carrier fillers are incorporated. Two mainstream pure crystal variants exist in industrial supply chains, each with fully disclosed native composition without extraneous substances.
1. Anhydrous High-Purity Magnesium Orotate (Zero Lattice Water, No Fillers)
This anhydrous crystal form contains only the intrinsic chelate molecular complex, with no water trapped in the crystal lattice and no foreign filler components whatsoever.
Intrinsic chemical composition (single pure active component, no auxiliary ingredients)
The sole molecular compound: anhydrous magnesium orotate, molecular formula C10H6MgN4O6, formed by the fixed 1:2 stoichiometric chelation of one magnesium divalent cation and two orotate anions.
Elemental constituents (only five inherent elements, no other elemental impurities as primary ingredients)
Carbon (C), Hydrogen (H), Magnesium (Mg), Nitrogen (N), Oxygen (O). No silicon, phosphorus, sulfur, calcium or other mineral filler elements are intentionally added.
Trace residual non-ingredient impurities (not classified as formulation fillers, only unavoidable micro-synthesis residues strictly controlled below pharmacopoeia limits)
Tiny residual unreacted orotic acid starting material, trace magnesium carbonate precursor, minimal ethanol recrystallization solvent residue, and ppm-level heavy metal trace contaminants (lead, arsenic, cadmium, mercury). These are manufacturing trace impurities, not intentional added fillers, and are further reduced via secondary recrystallization to meet ≥98.5% assay purity thresholds for high-purity grades.
2. Tetrahydrate High-Purity Magnesium Orotate (Dominant Commercial No-Filler Grade)
This is the most widely circulated pure raw material for nutritional supplements, food fortification and oral pharmaceutical intermediates; it contains no external fillers, only the core chelate complex plus naturally embedded lattice water that is part of the crystal intrinsic structure rather than an added additive.
Sole native active ingredient complex
Magnesium orotate tetrahydrate, molecular formula C10H12MgN4O10. The core chelate skeleton remains 1 Mg2+ coordinated with two orotate anions; four water molecules are bound within the crystal lattice via weak hydrogen bonds and are not blended as an external filler or diluent.
Full intrinsic elemental composition
Carbon, Hydrogen, Magnesium, Nitrogen, Oxygen. The hydrogen and oxygen present in lattice water are integral to the crystal’s natural molecular arrangement, not separate added water or filler agents introduced post-synthesis.
Distinction between lattice water and artificial filler additives
Lattice water forms during cooling crystallization and cannot be physically separated from the crystal without high-temperature dehydration; it is an inherent structural component of the pure crystal. In contrast, fillers such as maltodextrin, starch and silica are separately mixed into finished supplement tablets/capsules during downstream formulation processing and are absent from this bulk pure raw material.
3. Dihydrate High-Purity Magnesium Orotate (EU Novel Food Approved No-Filler Variant)
A standardized pure crystal form authorized by EFSA as a novel food source of magnesium, manufactured without any filler blending at the raw material stage.
Core native ingredient
Magnesium orotate dihydrate, molecular formula C10H10MgN4O8, featuring two bound lattice water molecules integrated into the crystal framework, no external diluents or carriers added.
Elemental makeup identical to other pure magnesium orotate variants: carbon, hydrogen, magnesium, nitrogen, oxygen, with no supplementary filler elements introduced.
4. Clear Definition of “No Additional Fillers” for Raw Material Grade
The no-filler specification applies exclusively to bulk crystalline magnesium orotate powder before downstream capsule, tablet or compound formula processing. It means the raw material producer does not incorporate any of the following common filler excipients at the synthesis, crystallization or drying stage:
· Bulking diluents: rice flour, corn starch, maltodextrin, lactose, microcrystalline cellulose
· Anti-caking agents: colloidal silicon dioxide, talc
· Lubricants: magnesium stearate, stearic acid
· Sweeteners, flavorings, preservatives or other functional auxiliary additives
All high-purity no-filler magnesium orotate only retains its single native chelate crystal compound (anhydrous, dihydrate or tetrahydrate) plus unavoidable trace micro-impurities from production, with zero intentional filler addition to adjust bulk density, flowability or formulation weight.
5. Original Ingredient List Format for Labeling High-Purity No-Filler Magnesium Orotate
Standard raw material label ingredient statement (tetrahydrate grade, zero fillers)
100% Magnesium Orotate Tetrahydrate (CAS 34717-03-8)
No other ingredients, no fillers, no excipients, no diluents, no anti-caking agents.
Anhydrous grade no-filler ingredient statement
100% Anhydrous Magnesium Orotate (CAS 34717-03-8)
No added carriers, starches, sugars or processing aids.
Dihydrate EU novel food no-filler ingredient statement
100% Magnesium Orotate Dihydrate
Unblended pure crystalline raw material, free of all filler additives.
High-purity filler-free magnesium orotate relies solely on its intrinsic chelate crystal compound as the sole active ingredient, available in anhydrous, dihydrate and tetrahydrate natural crystal forms distinguished only by the quantity of lattice-bound water molecules integrated into its native molecular structure. Its original ingredient list contains no externally blended bulking agents, anti-caking powders, lubricants or diluents; the only constituent elements are carbon, hydrogen, magnesium, nitrogen and oxygen, with trace manufacturing micro-impurities present at controlled ppm levels and not classified as added fillers. This unmodified pure crystalline raw material is the benchmark no-filler magnesium orotate source used for clean-label nutritional formulations, pharmaceutical raw material compounding and standardized cell culture medium production.
