High purity Fmoc-Gly-OH Supplier

Product Definition

Fmoc-Gly-OH (N-α-(9-fluorenylmethoxycarbonyl)-glycine) is a protected amino acid derivative supplied by Baishixing for pharmaceutical and research peptide synthesis, addressing the need for high-purity monomer with reliable lot-to-lot consistency.

Core Selling Points

Purity ≥99.0% by HPLC – Reproducible coupling yields in solid-phase peptide synthesis, with fewer deletion sequences and reduced purification burden.
Chloride content ≤0.05% – Minimizes acid-catalyzed side reactions during Fmoc deprotection and chain elongation.
Solubility ≥200 mg/mL in DMF – Allows convenient preparation of high-concentration coupling solutions without particulates.
Documented COA per batch – Includes IR, NMR, and HPLC data for GMP-style batch traceability and regulatory submissions.
Supply packaging from 100 g to 25 kg – Flexible for research-scale through pilot-plant production, with custom packaging options.

Detailed Technical Parameters

Parameter	Value	Supplementary Explanation
CAS Number	29022-11-3	Chemical Abstracts identifier
Molecular Formula	C₁₇H₁₅NO₄
Molecular Weight	297.31 g/mol	Calculated from atomic weights
Purity (by HPLC)	≥99.0%	Area normalization method
Appearance	White to off-white powder	Visual inspection
Melting Point	174–176 °C	Decomposition begins above 180 °C
Loss on Drying	≤0.5%	2 h at 60 °C under vacuum
Chloride (as Cl)	≤0.05%	Ion chromatography
Solubility	≥200 mg/mL in DMF	Clear solution at 25 °C
Storage Condition	2–8 °C, sealed, dry	Protect from light
Shelf Life	24 months	Under recommended storage

Applicable Scenarios

Solid-phase peptide synthesis (SPPS) in research labs – Use as a building block to assemble glycine-containing peptide chains with minimal side products.
Large-scale peptide API manufacturing – Consistent impurity profile reduces costly final purification steps and improves batch yield.
Drug discovery custom peptide libraries – High purity lowers false positives in high-throughput screening assays.
Contract development and manufacturing (CDMO) processes – Full documentation supports technology transfer and regulatory filing.

Frequently Asked Questions

What is the CAS number of Fmoc-Gly-OH?
The CAS number is 29022-11-3.

What purity is available for Fmoc-Gly-OH?
We supply purity ≥99.0% as determined by HPLC. Each batch includes a COA with actual chromatographic data.

How should Fmoc-Gly-OH be stored?
Store in a sealed, moisture-proof container at 2–8 °C, away from light. Under these conditions, shelf life is 24 months.

What solvents are recommended for dissolving Fmoc-Gly-OH?
Dimethylformamide (DMF) is the standard solvent; solubility is at least 200 mg/mL at 25 °C. DMSO also works for peptide coupling.

Do you provide COA and MSDS with shipments?
Yes, every shipment includes a certificate of analysis with purity, chloride, and residual solvent data. MSDS is available upon request.

Can you supply larger quantities for manufacturing?
We offer batch sizes from 100 g to 25 kg, with scale-up to 100 kg available depending on lead time.

What is the melting point of Fmoc-Gly-OH?
The typical melting point is 174–176 °C. Thermal decomposition may begin near 180 °C.

Is Fmoc-Gly-OH stable under standard SPPS conditions?
Yes. The Fmoc protecting group is stable to most acid treatments used during chain assembly. Deprotection is achieved with 20% piperidine in DMF.

Differentiation Summary

Compared with generic suppliers, Baishixing provides specific impurity profiling (chloride and residual solvents) and a complete COA for each lot, which directly reduces troubleshooting time in peptide synthesis. For researchers and manufacturers who need reproducible coupling efficiency and documented quality for scale-up or regulatory use, this product offers a practical balance of high purity and traceable support.