High purity Fmoc-Gly-OH Marke Price

Fmoc-Gly-OH (9-fluorenylmethoxycarbonyl-glycine) is a high-purity Fmoc-protected glycine derivative designed for chemists performing solid-phase peptide synthesis (SPPS), providing reliable building blocks that minimize racemization and unwanted side reactions.

Core Selling Points

HPLC purity ≥98.5% – Reduces byproduct formation during coupling, increasing final peptide yield without additional purification steps.
Batch-to-batch consistency – Each lot is tested for melting point (174–179 °C) and optical purity, enabling reproducible synthesis across different experiments.
High solubility in standard solvents – Solubility exceeds 100 mg/mL in DMF and 50 mg/mL in DCM at 25 °C, ensuring smooth operation with automated synthesizers.
Extended shelf life of 24 months – Inert gas packaging and strict moisture control preserve chemical integrity during long-term storage.

Detailed Parameter Table

Parameter	Value	Additional Notes
Product Name	Fmoc-Gly-OH	IUPAC: 9H-fluoren-9-ylmethyl (carboxymethyl)carbamate
CAS Number	29022-11-3	–
Molecular Formula	C17H15NO4	–
Molecular Weight	297.31 g/mol	–
Purity (HPLC)	≥98.5%	Determined by reverse-phase HPLC at 254 nm
Appearance	White to off-white crystalline powder	–
Melting Point	174–179 °C	–
Loss on Drying	≤0.5%	After 3 h at 105 °C
Heavy Metals	≤10 ppm	ICP-MS analysis
Storage Temperature	2–8 °C	Keep sealed, away from light and moisture
Solubility	>100 mg/mL in DMF; >50 mg/mL in DCM	Tested at 25 °C

Application Scenarios

Solid-phase peptide synthesis (SPPS): Chemists use Fmoc-Gly-OH as the first residue when targeting C-terminal glycine peptides, reducing racemization during the initial coupling step.
Combinatorial drug discovery: Research teams building peptide libraries rely on this product's consistent reactivity and high coupling efficiency for parallel synthesis.
Bioconjugation development: Scientists preparing peptide–antibody conjugates use the stable Fmoc group to ensure complete protection during chain assembly.
Industrial custom peptide production: Process engineers scale from grams to kilograms with confidence, since the product's consistent quality eliminates re-optimization of coupling parameters.

FAQ

Is Fmoc-Gly-OH compatible with automated peptide synthesizers?

Yes, the compound dissolves quickly in DMF and DCM, making it compatible with standard coupling chemistries such as HBTU/HATU or DIC/HOBt.

What coupling time is recommended when using Fmoc-Gly-OH?

For manual SPPS, a 2–4 h coupling in DMF at room temperature is typical; for automated instruments, double coupling is advised to maximize yield.

How should I store Fmoc-Gly-OH after opening?

Store at 2–8 °C in a dry, inert atmosphere, and re-seal the container tightly after each use. This prevents hydrolysis of the Fmoc protecting group.

Can Fmoc-Gly-OH be coupled to a resin without activation?

No, activation with carbodiimides or phosphonium/uronium salts is required to form the active ester before reaction with the resin-bound amine.

What purity specification is guaranteed?

HPLC purity is ≥98.5%, verified by both UV and ELSD detection. A certificate of analysis (CoA) is supplied with each shipment.

Does Fmoc-Gly-OH work in microwave-assisted peptide synthesis?

Yes, the Fmoc group remains stable at standard microwave SPPS temperatures up to 80 °C, so it is fully compatible with microwave synthesizers.

Differentiation Summary

While many suppliers offer glycine derivatives with only basic purity statements, Fmoc-Gly-OH from Baishixing provides documented batch-specific CoAs, controlled particle size, and inert packaging that extends shelf life to 24 months. For laboratories requiring reproducible peptide synthesis and traceable documentation, this product delivers equivalent analytical performance to major global brands at a more economical price point. It is particularly suited for process chemistry teams who prioritize supply stability, regulatory support, and cost efficiency.