Fmoc-Gly-OH 29022-11-3 Bulk Supply

Fmoc-Gly-OH is a highly pure N-α-Fmoc-protected glycine derivative used in solid-phase peptide synthesis (SPPS), designed for research laboratories and pharmaceutical manufacturers that require reliable, batch-consistent building blocks.

Key Selling Points

Purity ≥ 99% (HPLC): Each batch is tested by high-performance liquid chromatography with a certificate of analysis (CoA) provided, reducing the risk of side reactions during coupling steps.
Low free glycine content ≤ 0.1%: Minimizes premature chain termination or insertion errors when synthesizing peptides for preclinical or GMP studies.
Bulk packaging options from 100 g to 25 kg: Enables scale-up from solid-phase synthesis optimization to pilot and commercial production without reformulation.
Stable storage up to 24 months at 2–8 °C: Properly sealed under inert gas, ensuring consistent coupling efficiency across long-term projects.
Batch-to-batch consistency with full traceability: Each lot is documented with impurity profile (HPLC area%), residual solvent (GC), and water content (KF), which supports process validation in regulated environments.

Detailed Specification Table

Parameter	Value	Additional Information
Product Name	Fmoc-Gly-OH	Fmoc-protected glycine, CAS 29022-11-3
Molecular Formula	C₁₇H₁₅NO₄	Molecular weight: 297.31 g/mol
Purity (HPLC)	≥ 99.0%	Area normalization method, tested per batch
Free Amino Content	≤ 0.1%	Determined by HPLC pre-derivatization
Water Content (KF)	≤ 0.5%	Karl Fischer titration
Appearance	White to off-white crystalline powder	Free-flowing, no visible aggregates
Melting Point	174–178 °C	Decomposition temperature on DSC
Solubility	Soluble in DMF, DCM, THF	50 mg/mL in DMF at 25 °C
Optical Rotation	[α]²⁰(D): -14.5° ± 1.0°	c = 1 in DMF
Storage Condition	2–8 °C, sealed, dry	Protect from light and moisture
Shelf Life	24 months from manufacturing date	Retest after opening recommended within 90 days
Packaging	100 g, 500 g, 1 kg, 5 kg, 25 kg	Custom sizes available for bulk orders

Applicable Use Cases

Research chemists synthesizing peptide libraries for drug discovery use Fmoc-Gly-OH as a standard monomer to introduce glycine residues with high coupling efficiency.
Peptide manufacturers scaling up SPPS processes rely on bulk quantities with low impurity levels to maintain consistent product yield across multiple cGMP campaigns.
Contract development organizations (CDMOs) developing generic peptide APIs select Fmoc-Gly-OH with full analytical documentation for method transfer and regulatory filing.
Biotech companies producing peptide-based cosmetics or nutraceuticals use this building block to achieve reproducible purity profiles in final products.
Academic laboratories teaching SPPS techniques use it as a benchmark reagent because of its predictable reactivity and straightforward analytical verification.

Common Questions from Users

What is the CAS number of Fmoc-Gly-OH?
The CAS registry number is 29022-11-3, corresponding to the Fmoc-protected glycine structure with molecular formula C₁₇H₁₅NO₄.

Is Fmoc-Gly-OH soluble in DCM?
Yes, it dissolves in dichloromethane at 100 mg/mL with mild heating, but DMF is the preferred solvent for standard coupling reactions.

How should Fmoc-Gly-OH be stored after opening the bottle?
Store it in a tightly sealed container at 2–8 °C under dry conditions, and minimize exposure to moisture and ambient light to prevent Fmoc group cleavage.

What is the recommended coupling time for this compound in SPPS?
With 2.5 equivalents of amino acid and HATU as activator, coupling is typically complete within 30 minutes at room temperature; use chloride salt monitoring to confirm.

Does this product contain any racemization during coupling?
Glycine has no chiral center, so racemization is not a concern; the main quality parameter is free amine content to avoid deletion sequences.

Can I receive a certificate of analysis (CoA) with each batch?
Yes, every batch ships with a CoA covering HPLC purity, water content, residual solvents, and appearance, along with an MSDS.

What is the bulk price per kilogram for pharmaceutical-grade supply?
Pricing depends on quantity and contract terms; contact the supplier for a current quote based on your annual volume and delivery schedule.

Is this product suitable for GMP peptide manufacturing?
It is manufactured under ISO 9001 quality management and can be supplied with additional documentation (e.g., or a CofA) to support non-GMP synthesis; site audits can be arranged for large-scale agreements.

Differentiation Summary

Compared with other Fmoc-glycine suppliers that offer only standard purity with limited batch analysis, Fmoc-Gly-OH from this product line provides a documented impurity profile, low free-glycine content, and flexible bulk packaging that scales directly from laboratory to production. The product is particularly suitable for drug discovery teams and commercial peptide manufacturers that need reproducible quality without the cost of custom qualification. For researchers prioritizing high coupling yields and batch traceability, this Fmoc-Gly-OH offers a practical balance of performance and supply-chain reliability.