Chemical Name: Fmoc-L-Met-OH
Molecular Formula: C22H25NO4S
Molecular Weight: 381.51 g/mol

Overview
Fmoc-L-Met-OH is a protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS). This compound features L-methionine, an essential amino acid, with its amino group protected by the Fmoc (9-fluorenylmethyloxycarbonyl) group. The Fmoc group is crucial for controlling the peptide synthesis process by preventing unwanted reactions and ensuring the precise incorporation of methionine into peptide chains.

Importance in Peptide Synthesis
The Fmoc strategy is highly favored in SPPS due to its efficiency and mild deprotection conditions, typically using a base such as piperidine. Fmoc-L-Met-OH is particularly important for incorporating methionine residues into peptides. Methionine, with its sulfur-containing side chain, is an essential amino acid that plays a key role in various biological processes.

Methionine's side chain includes a thioether group, which is less reactive compared to thiol groups found in other sulfur-containing amino acids. This property makes Fmoc-L-Met-OH valuable for peptide synthesis, as it helps in reducing unwanted side reactions while still allowing the methionine residue to contribute to the peptide's biological activity.

Applications
Fmoc-L-Met-OH is extensively used in the synthesis of peptides that require the inclusion of methionine residues. These peptides are significant in various fields, including drug development, enzyme studies, and biomaterial creation. Methionine-rich peptides are essential for studying protein synthesis, interactions, and functions.

Methionine is the initiator amino acid for protein synthesis in eukaryotes and many prokaryotes. Therefore, peptides containing methionine are crucial for studies related to translation initiation and protein synthesis mechanisms. Additionally, methionine-containing peptides are used in the development of peptide-based therapeutics and diagnostic tools, given their involvement in various cellular processes.

Handling and Storage
Fmoc-L-Met-OH should be handled with care, similar to other chemical reagents. It is typically stored in a cool, dry place, away from light and moisture, to prevent degradation. Proper storage conditions are essential to maintain the stability and reactivity of the compound, ensuring its suitability for peptide synthesis.

Conclusion
Fmoc-L-Met-OH is an essential reagent in peptide synthesis, enabling the precise incorporation of L-methionine into peptide sequences. Its role in SPPS is crucial for creating peptides with specific biological functions and activities, making it a valuable tool in advancing research in biochemistry, molecular biology, and drug development. The use of Fmoc-L-Met-OH continues to contribute to the fields of peptide synthesis and protein engineering, allowing scientists to design and create peptides that are integral to therapeutic applications and fundamental research.